Hinton C W
Department of Biology, College of Wooster, Ohio 44691.
Genetics. 1988 Dec;120(4):1035-42. doi: 10.1093/genetics/120.4.1035.
Optic morphology (Om) mutants associated with insertions of the tom transposable element at each of three tested loci are neomorphs as defined by the phenotypic equivalence of +/+/Om with +/Om and of +/Om/Om with Om/Om. Mutants behaving as suppressors of Om mutants and mapping to at least six loci are recovered from the same source and in similar frequency as Om mutants. The semidominant and nonpleiotropic suppressors at four of the six loci display defective eye phenes themselves, and the phenotypically normal mutants at a fifth locus are suspected alleles of a gene represented by recessive furrowed eye mutants. These and other properties imply that the suppressors, like suppressible Om mutants, are neomorphic due to insertion of the tom element into a hypothetical sequence they share with other members of a set of genes involved in development of the eye. Concurrently premature expression of both the suppressor and suppressed mutants would allow interaction of their products just as in normal development.
与转座元件tom在三个测试位点中的每一个位点插入相关的视形态（Om）突变体是新形态突变体，这是根据+/+/Om与+/Om以及+/Om/Om与Om/Om的表型等效性来定义的。表现为Om突变体抑制子且定位于至少六个位点的突变体是从同一来源获得的，其频率与Om突变体相似。六个位点中的四个位点的半显性和非多效性抑制子自身表现出眼睛表型缺陷，第五个位点的表型正常的突变体被怀疑是由隐性皱缩眼突变体所代表的基因的等位基因。这些以及其他特性表明，这些抑制子与可抑制的Om突变体一样，是由于tom元件插入到与一组参与眼睛发育的基因的其他成员共有的假设序列中而产生的新形态突变体。同时，抑制子和被抑制突变体的过早表达将允许它们的产物相互作用，就像在正常发育中一样。
