• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

叉状位点抑制子的突变会增加黑腹果蝇中吉普赛编码转录本的积累。

Mutations at the suppressor of forked locus increase the accumulation of gypsy-encoded transcripts in Drosophila melanogaster.

作者信息

Parkhurst S M, Corces V G

出版信息

Mol Cell Biol. 1986 Jun;6(6):2271-4. doi: 10.1128/mcb.6.6.2271-2274.1986.

DOI:10.1128/mcb.6.6.2271-2274.1986
PMID:3023926
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC367771/
Abstract

We studied the effect of mutations at the suppressor of forked [su(f)] locus in Drosophila melanogaster on the accumulation of transcripts encoded by the gypsy transposable element. Mutations at this locus do not affect the pattern of developmental expression of gypsy, but they cause an increase in the total amount of gypsy RNA present at different stages of development as compared with wild-type or su(f)/+ flies. These results suggest that the su(f)-encoded products acts as a negative regulator of gypsy expression.

摘要

我们研究了果蝇中叉状抑制因子[su(f)]位点的突变对gypsy转座因子编码转录本积累的影响。该位点的突变不影响gypsy的发育表达模式，但与野生型或su(f)/+果蝇相比，它们会导致在不同发育阶段存在的gypsy RNA总量增加。这些结果表明，由su(f)编码的产物作为gypsy表达的负调节因子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c5c/367771/fcf1a86ce63b/molcellb00090-0429-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c5c/367771/53b966a280ec/molcellb00090-0428-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c5c/367771/e98d7af4acd4/molcellb00090-0428-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c5c/367771/87269614db44/molcellb00090-0428-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c5c/367771/fcf1a86ce63b/molcellb00090-0429-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c5c/367771/53b966a280ec/molcellb00090-0428-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c5c/367771/e98d7af4acd4/molcellb00090-0428-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c5c/367771/87269614db44/molcellb00090-0428-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c5c/367771/fcf1a86ce63b/molcellb00090-0429-a.jpg

相似文献

1
Mutations at the suppressor of forked locus increase the accumulation of gypsy-encoded transcripts in Drosophila melanogaster.叉状位点抑制子的突变会增加黑腹果蝇中吉普赛编码转录本的积累。
Mol Cell Biol. 1986 Jun;6(6):2271-4. doi: 10.1128/mcb.6.6.2271-2274.1986.
2
Forked, gypsys, and suppressors in Drosophila.
Cell. 1985 Jun;41(2):429-37. doi: 10.1016/s0092-8674(85)80016-7.
3
Interactions among the gypsy transposable element and the yellow and the suppressor of hairy-wing loci in Drosophila melanogaster.黑腹果蝇中吉普赛转座因子与黄色基因座及毛翅抑制因子基因座之间的相互作用。
Mol Cell Biol. 1986 Jan;6(1):47-53. doi: 10.1128/mcb.6.1.47-53.1986.
4
Alteration of hsp82 gene expression by the gypsy transposon and suppressor genes in Drosophila melanogaster.黑腹果蝇中gypsy转座子和抑制基因对hsp82基因表达的改变。
Genes Dev. 1989 Apr;3(4):454-68. doi: 10.1101/gad.3.4.454.
5
Excess function hairy-wing mutations caused by gypsy and copia insertions within structural genes of the achaete-scute locus of Drosophila.由果蝇无刚毛-小盾片基因座结构基因内的gypsy和copia插入引起的功能过剩的毛翅突变。
Cell. 1986 Jan 31;44(2):303-12. doi: 10.1016/0092-8674(86)90764-6.
6
The Drosophila su(Hw) gene, which controls the phenotypic effect of the gypsy transposable element, encodes a putative DNA-binding protein.果蝇的抑制子（Hairy-wing）基因（su(Hw)）控制着吉普赛转座因子的表型效应，该基因编码一种假定的DNA结合蛋白。
Genes Dev. 1988 Oct;2(10):1205-15. doi: 10.1101/gad.2.10.1205.
7
Drosophila melanogaster mutations suppressible by the suppressor of Hairy-wing are insertions of a 7.3-kilobase mobile element.可被毛翅抑制子抑制的黑腹果蝇突变是一个7.3千碱基移动元件的插入。
Proc Natl Acad Sci U S A. 1983 Mar;80(6):1678-82. doi: 10.1073/pnas.80.6.1678.
8
The gypsy retrotransposon of Drosophila melanogaster: mechanisms of mutagenesis and interaction with the suppressor of Hairy-wing locus.黑腹果蝇的吉普赛逆转座子：诱变机制及与毛翅位点抑制因子的相互作用
Dev Genet. 1989;10(3):239-48. doi: 10.1002/dvg.1020100313.
9
Dominant effects of suppressor of Hairy-wing mutations on gypsy-induced alleles of forked and cut in Drosophila melanogaster.毛翅抑制子突变对黑腹果蝇中由吉普赛诱导的叉毛和缺刻等位基因的显性效应。
Genetics. 1992 Nov;132(3):691-7. doi: 10.1093/genetics/132.3.691.
10
Effects of transposable elements on the expression of the forked gene of Drosophila melanogaster.转座元件对黑腹果蝇叉毛基因表达的影响。
Genetics. 1993 Oct;135(2):507-26. doi: 10.1093/genetics/135.2.507.

引用本文的文献

1
Evolution of genome structure in the species complex.在 种复合体中基因组结构的演化。
Genome Res. 2021 Mar;31(3):380-396. doi: 10.1101/gr.263442.120. Epub 2021 Feb 9.
2
Effects of a transposable element insertion on alcohol dehydrogenase expression in Drosophila melanogaster.转座因子插入对黑腹果蝇乙醇脱氢酶表达的影响。
Genetics. 1995 Jun;140(2):667-77. doi: 10.1093/genetics/140.2.667.
3
The SPT6 gene is essential for growth and is required for delta-mediated transcription in Saccharomyces cerevisiae.SPT6基因对酿酒酵母的生长至关重要，且是δ介导转录所必需的。

本文引用的文献

1
Excision of the DBA ecotropic provirus in dilute coat-color revertants of mice occurs by homologous recombination involving the viral LTRs.在小鼠稀释毛色回复突变体中，DBA嗜亲性前病毒的切除是通过涉及病毒长末端重复序列（LTRs）的同源重组发生的。
Cell. 1983 Jun;33(2):379-87. doi: 10.1016/0092-8674(83)90419-1.
2
Drosophila melanogaster mutations suppressible by the suppressor of Hairy-wing are insertions of a 7.3-kilobase mobile element.可被毛翅抑制子抑制的黑腹果蝇突变是一个7.3千碱基移动元件的插入。
Proc Natl Acad Sci U S A. 1983 Mar;80(6):1678-82. doi: 10.1073/pnas.80.6.1678.
3
Effects of transposable element insertions on RNA encoded by the white gene of Drosophila.
Mol Cell Biol. 1987 Feb;7(2):679-86. doi: 10.1128/mcb.7.2.679-686.1987.
4
Formal relations between Om mutants and their suppressors in Drosophila ananassae.果蝇中Om突变体与其抑制因子之间的形式关系。
Genetics. 1988 Dec;120(4):1035-42. doi: 10.1093/genetics/120.4.1035.
5
Isolation and analysis of a novel class of suppressor of Ty insertion mutations in Saccharomyces cerevisiae.酿酒酵母中一类新型Ty插入突变抑制子的分离与分析。
Genetics. 1988 Feb;118(2):203-12. doi: 10.1093/genetics/118.2.203.
6
Molecular study of the retrovirus-like transposable element 412, a 20-OH ecdysone responsive repetitive sequence in Drosophila cultured cells.逆转录病毒样转座元件412的分子研究，其为果蝇培养细胞中一种20-羟基蜕皮激素响应性重复序列。
Nucleic Acids Res. 1988 Jan 25;16(2):455-70. doi: 10.1093/nar/16.2.455.
7
A dosage-sensitive modifier of retrotransposon-induced alleles of the Drosophila white locus.
EMBO J. 1989 Mar;8(3):879-89. doi: 10.1002/j.1460-2075.1989.tb03449.x.
8
Suppression in Drosophila: su(Hw) and su(f) gene products interact with a region of gypsy (mdg4) regulating its transcriptional activity.果蝇中的抑制作用：su(Hw) 和 su(f) 基因产物与gypsy（mdg4）的一个调节其转录活性的区域相互作用。
EMBO J. 1989 Mar;8(3):903-11. doi: 10.1002/j.1460-2075.1989.tb03451.x.
9
Retrotransposon Gypsy and genetic instability in Drosophila (review).
Genetica. 1991;85(1):13-22. doi: 10.1007/BF00056102.
10
The suppressor of forked locus in Drosophila melanogaster: genetic and molecular analyses.黑腹果蝇中叉状基因座的抑制因子：遗传与分子分析
Genetica. 1992;85(3):185-203. doi: 10.1007/BF00132271.
转座元件插入对果蝇白色基因编码的RNA的影响。
Cell. 1984 Sep;38(2):471-81. doi: 10.1016/0092-8674(84)90502-6.
4
The developmental genetics of the temperature sensitive lethal allele of the suppressor of forked, 1(1)su(f)ts67g, in Drosophila melanogaster.果蝇中叉状抑制因子1(1)su(f)ts67g温度敏感致死等位基因的发育遗传学。
Genetics. 1974 Mar;76(3):487-510. doi: 10.1093/genetics/76.3.487.
5
Characterization and developmental expression of a Drosophila ras oncogene.果蝇ras癌基因的特征及发育表达
Mol Cell Biol. 1985 Apr;5(4):885-9. doi: 10.1128/mcb.5.4.885-889.1985.
6
Interactions among the gypsy transposable element and the yellow and the suppressor of hairy-wing loci in Drosophila melanogaster.黑腹果蝇中吉普赛转座因子与黄色基因座及毛翅抑制因子基因座之间的相互作用。
Mol Cell Biol. 1986 Jan;6(1):47-53. doi: 10.1128/mcb.6.1.47-53.1986.
7
Forked, gypsys, and suppressors in Drosophila.
Cell. 1985 Jun;41(2):429-37. doi: 10.1016/s0092-8674(85)80016-7.
8
A detailed developmental and structural study of the transcriptional effects of insertion of the Copia transposon into the white locus of Drosophila melanogaster.对Copia转座子插入黑腹果蝇白色基因座的转录效应进行的详细发育和结构研究。
Genetics. 1985 Nov;111(3):495-515. doi: 10.1093/genetics/111.3.495.