Siddique T, McKinney R, Hung W Y, Bartlett R J, Bruns G, Mohandas T K, Ropers H H, Wilfert C, Roses A D
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
Genomics. 1988 Aug;3(2):156-60. doi: 10.1016/0888-7543(88)90147-4.
Sensitivity to nonmodified poliovirus infection is an autosomal dominant trait, specific to primates. The gene for poliovirus sensitivity (PVS) is encoded on human chromosome 19. In order to sublocalize the PVS gene, we infected rodent-human hybrid cell lines that divide human chromosome 19 into four regions with poliovirus 1 and/or 3. When infected, these hybrid cell lines showed the typical cytopathic effect of poliovirus infection only if they contained 19q12----q13.2 as the smallest region of overlap. Appropriate negative and positive controls were used. PVS may be of relevance to myotonic dystrophy (DM) and the inherited motor neuron diseases: to DM because it localizes to the same region of chromosome 19 and to the inherited motor neuron diseases because it encodes a cell-surface receptor expressed on motor neurons.
对未修饰的脊髓灰质炎病毒感染的敏感性是一种灵长类特有的常染色体显性性状。脊髓灰质炎病毒敏感性（PVS）基因在人类19号染色体上编码。为了对PVS基因进行亚定位，我们用脊髓灰质炎病毒1型和/或3型感染了将人类19号染色体分为四个区域的啮齿动物-人类杂交细胞系。感染时，这些杂交细胞系只有在包含19q12----q13.2作为最小重叠区域时，才会表现出脊髓灰质炎病毒感染的典型细胞病变效应。使用了适当的阴性和阳性对照。PVS可能与强直性肌营养不良（DM）和遗传性运动神经元疾病相关：与DM相关是因为它定位于19号染色体的同一区域，与遗传性运动神经元疾病相关是因为它编码运动神经元上表达的一种细胞表面受体。
