Schonk D, van Dijk P, Riegmann P, Trapman J, Holm C, Willcocks T C, Sillekens P, van Venrooij W, Wimmer E, Geurts van Kessel A
Department of Human Genetics, University of Nijmegen, The Netherlands.
Cytogenet Cell Genet. 1990;54(1-2):15-9. doi: 10.1159/000132946.
Hybridization studies using a panel of somatic cell hybrids with subchromosomal segments of 19q have localized the genes encoding hormone-sensitive lipase (LIPE), carcinoembryonic antigen (CEA), and small nuclear ribonucleoprotein polypeptide A (SNRPA) to various regions of 19q13.1; the cellular receptor for poliovirus sensitivity (PVS) to 19q13.2; and the genes coding for prostate-specific antigen (APS), human pancreatic kallikrein (KLK1), and small nuclear ribonucleoprotein 70-kD polypeptide (SNRP70) to 19q13.3----qter. Our results exclude several of these genes from being seriously considered as a candidate for the myotonic dystrophy gene on 19q.
利用一组含有19号染色体亚染色体片段的体细胞杂种进行的杂交研究，已将编码激素敏感性脂肪酶（LIPE）、癌胚抗原（CEA）和小核核糖核蛋白多肽A（SNRPA）的基因定位到19q13.1的不同区域；将脊髓灰质炎病毒敏感性细胞受体（PVS）定位到19q13.2；将编码前列腺特异性抗原（APS）、人胰激肽释放酶（KLK1）和小核核糖核蛋白70-kD多肽（SNRP70）的基因定位到19q13.3----qter。我们的结果排除了其中几个基因作为19号染色体上强直性肌营养不良基因候选基因的可能性。
