Skacelova Martina, Pavel Horak, Zuzana Hermanova, Katerina Langova
Department of Internal Medicine III - Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc. Czech Republic.
Department of Immunology, University Hospital Olomouc, Olomouc. Czech Republic.
Curr Rheumatol Rev. 2017;13(3):224-230. doi: 10.2174/1573397113666170517160726.
Rheumatoid arthritis is a chronic disease considerably affecting the quality of life of patients, their functional abilities and capability to work. In everyday clinical practice, the condition is commonly monitored by assessing the disease activity using a joint count and laboratory markers of inflammation with calculating the DAS28 or other systems for scoring the disease activity.
This study is aimed to evaluate the benefit of ultrasound examination with a standardized instrument and correlate its results with the quality of life of patients and their functional abilities as assessed by standardized questionnaire methods.
98 rheumatoid arthritis patients were assessed clinically for disease activity and ultrasound examination with assessment of German US 7 score was performed. The data from patientreported outcomes (Stanford Health Assessment Questionnaire and the EQ-5D instrument) were collected.
The results of ultrasound examination were correlated with both disease activity and patient- assessed quality of life and limitations to daily activities. A very good predictor of impaired quality of life mainly appears to be the presence of synovitis detected by grayscale (GS) ultrasonography, shown to be significantly negatively correlated with patient mobility (r=-0.268, p=0.017), self-care (r-0.349, p= 0.002) and usual activities (r=-0.264, p= 0.019) as well as with patients' global health assessment (r=-0.243, p= 0.031).
The study results showed a direct relationship between rheumatoid arthritis activity assessed with the US7 and patients' impaired functional abilities, mobility, self-care and usual activities.
类风湿性关节炎是一种慢性疾病，严重影响患者的生活质量、功能能力和工作能力。在日常临床实践中，通常通过关节计数和炎症实验室指标评估疾病活动度，并计算DAS28或其他疾病活动度评分系统来监测病情。
本研究旨在评估使用标准化仪器进行超声检查的益处，并将其结果与通过标准化问卷方法评估的患者生活质量及其功能能力相关联。
对98例类风湿性关节炎患者进行临床疾病活动度评估，并使用德国超声7分法进行超声检查。收集患者报告结局（斯坦福健康评估问卷和EQ-5D工具）的数据。
超声检查结果与疾病活动度以及患者评估的生活质量和日常活动受限情况均相关。生活质量受损的一个很好的预测指标似乎主要是灰阶（GS）超声检查发现的滑膜炎，它与患者的活动能力（r=-0.268，p=0.017）、自我护理能力（r=-0.349，p=0.002）和日常活动能力（r=-0.264，p=0.019）以及患者的整体健康评估（r=-0.243，p=0.031）均呈显著负相关。
研究结果表明，用US7评估的类风湿性关节炎活动度与患者受损的功能能力、活动能力、自我护理能力和日常活动能力之间存在直接关系。
