van Beers-Tas Marian H, Ter Wee Marieke M, van Tuyl Lilian H, Maat Bertha, Hoogland Wijnanda, Hensvold Aase H, Catrina Anca I, Mosor Erika, Stamm Tanja A, Finckh Axel, Courvoisier Delphine S, Filer Andrew, Sahbudin Ilfita, Stack Rebecca J, Raza Karim, van Schaardenburg Dirkjan
Amsterdam Rheumatology and Immunology Center, Reade, Amsterdam, The Netherlands.
Amsterdam Rheumatology and Immunology Center, Amsterdam Medical Center, Amsterdam, The Netherlands.
RMD Open. 2018 May 21;4(1):e000641. doi: 10.1136/rmdopen-2017-000641. eCollection 2018.
To describe the development and assess the psychometric properties of the novel 'Symptoms in Persons At Risk of Rheumatoid Arthritis' (SPARRA) questionnaire in individuals at risk of rheumatoid arthritis (RA) and to quantify their symptoms.
The questionnaire items were derived from a qualitative study in patients with seropositive arthralgia. The questionnaire was administered to 219 individuals at risk of RA on the basis of symptoms or autoantibody positivity: 74% rheumatoid factor and/or anticitrullinated protein antibodies positive, 26% seronegative. Validity, reliability and responsiveness were assessed. Eighteen first degree relatives (FDR) of patients with RA were used for comparison.
Face and content validity were high. The test-retest showed good agreement and reliability (1 week and 6 months). Overall, construct validity was low to moderate, with higher values for concurrent validity, suggesting that some questions reflect symptom content not captured with regular Visual Analogue Scale pain/well-being. Responsiveness was low (small subgroup). Finally, the burden of symptoms in both seronegative and seropositive at risk individuals was high, with pain, stiffness and fatigue being the most common ones with a major impact on daily functioning. The FDR cohort (mostly healthy individuals) showed a lower burden of symptoms; however, the distribution of symptoms was similar.
The SPARRA questionnaire has good psychometric properties and can add information to currently available clinical measures in individuals at risk of RA. The studied group had a high burden and impact of symptoms. Future studies should evaluate whether SPARRA data can improve the prediction of RA in at risk individuals.
描述新型“类风湿关节炎风险人群症状”（SPARRA）问卷的开发过程，并评估其在类风湿关节炎（RA）风险个体中的心理测量学特性，同时对他们的症状进行量化。
问卷项目源自对血清阳性关节痛患者的定性研究。基于症状或自身抗体阳性，对219名RA风险个体进行问卷调查：74%类风湿因子和/或抗瓜氨酸化蛋白抗体呈阳性，26%为血清阴性。评估问卷的有效性、可靠性和反应性。选取18名RA患者的一级亲属（FDR）进行比较。
表面效度和内容效度较高。重测结果显示一致性和可靠性良好（间隔1周和6个月）。总体而言，结构效度低至中等，同时效度值较高，这表明一些问题反映了常规视觉模拟评分法疼痛/健康状况未涵盖的症状内容。反应性较低（小亚组）。最后，血清阴性和血清阳性风险个体的症状负担都很高，疼痛、僵硬和疲劳最为常见，对日常功能有重大影响。FDR队列（大多为健康个体）的症状负担较低；然而，症状分布相似。
SPARRA问卷具有良好的心理测量学特性，可为RA风险个体目前可用的临床测量提供补充信息。研究组的症状负担和影响较高。未来研究应评估SPARRA数据是否能改善对风险个体RA的预测。
