Hellevik Alf Inge, Johnsen Marianne Bakke, Langhammer Arnulf, Fenstad Anne Marie, Furnes Ove, Storheim Kjersti, Zwart John Anker, Flugsrud Gunnar, Nordsletten Lars
The HUNT Research Centre, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Levanger, Norway.
Division of Orthopaedic Surgery, Oslo University Hospital, Oslo, Norway.
BMC Musculoskelet Disord. 2017 May 18;18(1):201. doi: 10.1186/s12891-017-1565-6.
To study whether thyroid function was associated with risk of hip or knee replacement due to primary osteoarthritis.
In a prospective cohort study, data from the second and third survey of the Nord-Trøndelag Health Study were linked to the Norwegian Arthroplasty Register in order to identify total hip or knee replacement as a result of primary osteoarthritis.
Among 37 891 participants without previously known thyroid disease we recorded 978 total hip replacements (THRs) and 538 total knee replacements (TKRs) during a median follow-up time of 15.7 years. The analyses were adjusted for sex, age, BMI (body mass index), smoking, physical activity and diabetes. We did not find any association between TSH (thyroid stimulating hormone) and THR or TKR due to osteoarthritis. Neither were changes in TSH over time, or overt hypo- or hyperthyroidism, associated with incidence of THR or TKR.
No association was found between thyroid function and hip or knee joint replacement due to osteoarthritis.
研究甲状腺功能是否与原发性骨关节炎导致的髋关节或膝关节置换风险相关。
在一项前瞻性队列研究中，北特伦德拉格健康研究第二次和第三次调查的数据与挪威关节成形术登记处相关联，以确定原发性骨关节炎导致的全髋关节或膝关节置换情况。
在37891名既往无甲状腺疾病的参与者中，在中位随访时间15.7年期间，我们记录了978例全髋关节置换术（THR）和538例全膝关节置换术（TKR）。分析对性别、年龄、体重指数（BMI）、吸烟、体力活动和糖尿病进行了校正。我们未发现促甲状腺激素（TSH）与骨关节炎导致的THR或TKR之间存在任何关联。TSH随时间的变化以及明显的甲状腺功能减退或亢进也与THR或TKR的发生率无关。
未发现甲状腺功能与骨关节炎导致的髋关节或膝关节置换之间存在关联。
