Grenoble Alpes Univ., F-38000 Grenoble, France; CEA LETI MlNATEC Campus, F-38054 Grenoble, France; Grenoble Alpes Univ., CERMAV-CNRS, F-38000 Grenoble, France.
Grenoble Alpes Univ., F-38000 Grenoble, France; CEA LETI MlNATEC Campus, F-38054 Grenoble, France.
Carbohydr Polym. 2017 Aug 15;170:166-175. doi: 10.1016/j.carbpol.2017.04.060. Epub 2017 Apr 25.
Semi-interpenetrating chitosan (CS)/poly(ethylene glycol) (PEG) sponges were designed by crosslinking PEG in the CS matrix via nucleophilic thiol-yne addition. This reaction does not require the use of any potentially cytotoxic catalytic species and offers possibilities to prepare materials with tunable properties. The molecular structure of the sponges was analyzed by FTIR spectroscopy, which provided evidence of intermolecular interactions between PEG and CS, and the presence of a cross-linked PEG network in the CS matrix. The crosslinked CS/PEG sponges displayed a structure with large interconnected pores (tens of micrometers) as demonstrated by scanning electron miscoscopy, in comparison to blended materials with irregular and smaller pores. The crosslinked sponges also exhibited improved mechanical properties (higher Young's modulus) and stability at physiological pH. All together, these interesting properties open the way for the application of this biomaterial in topical drug delivery.
半互穿壳聚糖（CS）/聚乙二醇（PEG）海绵通过亲核硫醇-炔加成将 PEG 交联到 CS 基质中设计而成。该反应不需要使用任何潜在细胞毒性的催化物种，并提供了制备具有可调性质的材料的可能性。通过傅里叶变换红外光谱分析了海绵的分子结构，该光谱提供了 PEG 与 CS 之间分子相互作用的证据，以及 CS 基质中存在交联 PEG 网络的证据。交联 CS/PEG 海绵显示出具有大互连孔（数十微米）的结构，这与具有不规则和较小孔的混合材料相比有所不同。交联海绵还表现出改善的机械性能（更高的杨氏模量）和在生理 pH 下的稳定性。所有这些有趣的性质为这种生物材料在局部药物输送中的应用开辟了道路。
