一项针对中国1012名精子捐献者精液地理差异的回顾性队列研究。

A retrospective cohort study of geographic differences in the semen of 1,012 sperm donors in China.

作者信息

Zhao Qian-Cheng, Zhang Zhe, Zhao Lian-Ming, Deng Zhen-Feng, Gao Jiang-Man, Zhang Hong-Liang, Lin Hao-Cheng, Liu De-Feng, Mao Jia-Ming, Zhang Hai-Tao, Chen Yu-Long, Tang Wen-Hao, Jiang Hui

机构信息

Department of Human Sperm Bank, Peking University Third Hospital, Beijing, China.

Department of Urology, Peking University Third Hospital, Beijing, China.

出版信息

Transl Androl Urol. 2023 Feb 28;12(2):187-196. doi: 10.21037/tau-22-578. Epub 2023 Feb 7.

DOI:10.21037/tau-22-578

PMID:36915889

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10006001/

Abstract

BACKGROUND

Male reproductive health has become a serious public health concern, and semen quality is essential to male reproduction. We aimed to investigate geographical differences in the semen quality of sperm donors from northern and southern China by enrolling donors across the country.

METHODS

A total of 1,012 sperm donors were enrolled in this study between 2015 and 2019. Donors were first divided into two parts based on their birthplace according to the "Qinling-Huaihe" line, and secondly, by their residential latitude. Finally, donors were re-classified into two groups (typically north and south) which contained 667 samples.

RESULTS

Statistically significant differences in sperm concentration were observed among men from different latitudes in China (P=0.04). The sperm concentrations of males from 18° to 27° north latitude were significantly lower than those from 36° to 45° and 45° to 54° [median 131, 134, and 146, respectively, P=0.021 (18° to 27° 36° to 45°) and P=0.01 (18° to 27° 45° to 54°)].

CONCLUSION

We hypothesize environmental pollution and mental stress due to the increased population size may be the main factors underlying differences in the sperm quality of men in northern and southern China.

摘要

背景

男性生殖健康已成为一个严重的公共卫生问题，精液质量对男性生殖至关重要。我们旨在通过招募全国的精子捐献者来调查中国北方和南方精子捐献者精液质量的地理差异。

方法

2015年至2019年期间，共有1012名精子捐献者参与了本研究。捐献者首先根据其出生地按照“秦岭-淮河”线分为两部分，其次，根据其居住纬度进行划分。最后，捐献者被重新分为两组（典型的北方和南方），共包含667个样本。

结果

在中国不同纬度的男性中观察到精子浓度存在统计学上的显著差异（P = 0.04）。北纬18°至27°男性的精子浓度显著低于北纬36°至45°和45°至54°的男性[中位数分别为131、134和146，P = 0.021（18°至27°对36°至45°）和P = 0.01（18°至27°对45°至54°）]。