Pijls B G, Sanders I M J G, Kuijper E J, Nelissen R G H H
Leiden University Medical Centre, Albinusdreef 2, P.O. Box 9600, Postzone J-11-S, 2300 RC Leiden, The Netherlands
Leiden University Medical Centre, Albinusdreef 2, P.O. Box 9600, Postzone J-11-S, 2300 RC Leiden, The Netherlands.
Bone Joint Res. 2017 May;6(5):323-330. doi: 10.1302/2046-3758.65.BJR-2016-0308.R1.
Infection of implants is a major problem in elective and trauma surgery. Heating is an effective way to reduce the bacterial load in food preparation, and studies on hyperthermia treatment for cancer have shown that it is possible to heat metal objects with pulsed electromagnetic fields selectively (PEMF), also known as induction heating. We therefore set out to answer the following research question: is non-contact induction heating of metallic implants effective in reducing bacterial load ?
Titanium alloy cylinders (Ti6Al4V) were exposed to PEMF from an induction heater with maximum 2000 watts at 27 kHz after being contaminated with five different types of micro-organisms: ; spore-forming and yeast . The cylinders were exposed to incremental target temperatures (35°C, 45°C, 50°C, 55°C, 60°C, 65°C, 70°C) for up to 3.5 minutes.
There was an average linear heating rate of 0.39°C per second up to the target temperature, and thereafter the target temperature was maintained until the end of the experiment. At 60°C and higher (duration 3.5 minutes), there was a 6-log reduction or higher for every micro-organism tested. At 60°C, we found that the shortest duration of effective induction heating was 1.5 minutes. This resulted in a 5-log reduction or higher for every micro-organism tested.
Non-contact induction heating of a titanium disk is effective in reducing bacterial load . These promising results can be further explored as a new treatment modality for infections of metal orthopaedic implants.: B. G. Pijls, I. M. J. G. Sanders, E. J. Kuijper, R. G. H. H. Nelissen. Non-contact electromagnetic induction heating for eradicating bacteria and yeasts on biomaterials and possible relevance to orthopaedic implant infections: findings. 2017;6:323-330. DOI: 10.1302/2046-3758.65.BJR-2016-0308.R1.
植入物感染是择期手术和创伤手术中的一个主要问题。加热是减少食品制备中细菌负荷的有效方法，并且针对癌症的热疗研究表明，有可能用脉冲电磁场（PEMF）选择性地加热金属物体，也称为感应加热。因此，我们着手回答以下研究问题：金属植入物的非接触感应加热在降低细菌负荷方面是否有效？
钛合金圆柱体（Ti6Al4V）在被五种不同类型的微生物污染后，暴露于来自最大功率为2000瓦、频率为27千赫的感应加热器产生的脉冲电磁场中。这些微生物包括形成孢子的微生物和酵母菌。圆柱体被加热到递增的目标温度（35℃、45℃、50℃、55℃、60℃、65℃、70℃），持续时间长达3.5分钟。
在达到目标温度之前，平均线性加热速率为每秒0.39℃，此后目标温度保持到实验结束。在60℃及更高温度（持续3.5分钟）时，每种测试微生物的数量减少了6个对数或更多。在60℃时，我们发现有效感应加热的最短持续时间为1.5分钟。这导致每种测试微生物的数量减少了5个对数或更多。
钛盘的非接触感应加热在降低细菌负荷方面是有效的。这些有前景的结果可作为金属骨科植入物感染的一种新治疗方式作进一步探索。：B.G.皮尔斯、I.M.J.G.桑德斯、E.J.库伊珀、R.G.H.H.内利森。用于根除生物材料上细菌和酵母菌的非接触电磁感应加热及其与骨科植入物感染的可能关联：研究结果。2017；6：323 - 330。DOI：10.1302/2046 - 3758.65.BJR - 2016 - 0308.R1。
