McMaster Integrative Neuroscience Discovery and Study McMaster University Hamilton ON Canada.
Mood Disorders Program St. Joseph's Healthcare Hamilton ON Canada.
Brain Behav. 2017 Mar 31;7(5):e00664. doi: 10.1002/brb3.664. eCollection 2017 May.
The present study investigated resting fMRI connectivity within the default mode (DMN), salience (SN), and central executive (CEN) networks in relation to neurocognitive performance and symptom severity in trauma-exposed patients with major depressive disorder (MDD).
Group independent component analysis was conducted among patients with MDD ( = 21), examining DMN, SN, and CEN connectivity in relation to neurocognitive performance and symptom severity. Activation in these networks was also compared between the patient group and healthy controls ( = 20).
Among the patient group, higher levels of performance on measures of verbal memory and executive functioning were related to increased connectivity within the DMN (i.e., inferior parietal lobe; precuneus). Greater depression severity was related to reduced connectivity between the SN and a node of the DMN (i.e., posterior cingulate cortex) and higher depersonalization symptoms were related to enhanced connectivity between the SN and a node of the DMN (i.e., middle temporal gyrus). Higher symptoms of depersonalization were also associated with reduced integration of the DMN with the medial frontal gyrus. Relative to controls, patients with MDD showed greater connectivity of the ventromedial prefrontal cortex within the DMN.
Intrinsic connectivity network patterns are related to cognitive performance and symptom presentation among trauma-exposed patients with MDD.
本研究调查了创伤后患有重度抑郁症（MDD）的患者在静息状态下功能磁共振成像（fMRI）连接与神经认知表现和症状严重程度的关系，包括默认模式（DMN）、突显（SN）和中央执行（CEN）网络。
对 MDD 患者（n=21）进行了组独立成分分析，考察了 DMN、SN 和 CEN 连接与神经认知表现和症状严重程度的关系。还比较了这些网络在患者组和健康对照组（n=20）之间的激活情况。
在患者组中，言语记忆和执行功能测试的表现水平越高，与 DMN 内（即顶下小叶；楔前叶）连接增加有关。抑郁严重程度越高，与 SN 和 DMN 节点（即后扣带回皮质）之间的连接减少有关，而人格解体症状越严重，与 SN 和 DMN 节点（即颞中回）之间的连接增强有关。人格解体症状越高，还与 DMN 与内侧额回的整合减少有关。与对照组相比，MDD 患者的 DMN 中腹侧前额叶皮质的连接性更强。
创伤后患有 MDD 的患者的内在连接网络模式与认知表现和症状表现有关。
