Lu Shaojia, Pan Fen, Gao Weijia, Wei Zhaoguo, Wang Dandan, Hu Shaohua, Huang Manli, Xu Yi, Li Lingjiang
Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou, Zhejiang, China.
Department of Child Psychology, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Oncotarget. 2017 Aug 7;8(45):79843-79853. doi: 10.18632/oncotarget.20051. eCollection 2017 Oct 3.
The aim of this study was to investigate the relationship among childhood trauma, executive impairments, and altered resting-state brain function in young healthy adults. Twenty four subjects with childhood trauma and 24 age- and gender-matched subjects without childhood trauma were recruited. Executive function was assessed by a series of validated test procedures. Localized brain activity was evaluated by fractional amplitude of low frequency fluctuation (fALFF) method and compared between two groups. Areas with altered fALFF were further selected as seeds in subsequent functional connectivity analysis. Correlations of fALFF and connectivity values with severity of childhood trauma and executive dysfunction were analyzed as well. Subjects with childhood trauma exhibited impaired executive function as assessed by Wisconsin Card Sorting Test and Stroop Color Word Test. Traumatic individuals also showed increased fALFF in the right precuneus and decreased fALFF in the right superior temporal gyrus. Significant correlations of specific childhood trauma severity with executive dysfunction and fALFF value in the right precuneus were found in the whole sample. In addition, individuals with childhood trauma also exhibited diminished precuneus-based connectivity in default mode network with left ventromedial prefrontal cortex, left orbitofrontal cortex, and right cerebellum. Decreased default mode network connectivity was also associated with childhood trauma severity and executive dysfunction. The present findings suggest that childhood trauma is associated with executive deficits and aberrant default mode network functions even in healthy adults. Moreover, this study demonstrates that executive dysfunction is related to disrupted default mode network connectivity.
本研究的目的是调查年轻健康成年人童年创伤、执行功能障碍和静息态脑功能改变之间的关系。招募了24名有童年创伤的受试者和24名年龄及性别匹配的无童年创伤的受试者。通过一系列经过验证的测试程序评估执行功能。采用低频振幅分数（fALFF）方法评估局部脑活动，并在两组之间进行比较。在随后的功能连接分析中，将fALFF改变的区域进一步选为种子点。还分析了fALFF和连接值与童年创伤严重程度和执行功能障碍之间的相关性。通过威斯康星卡片分类测验和斯特鲁普色词测验评估，有童年创伤的受试者表现出执行功能受损。有创伤经历的个体在右侧楔前叶的fALFF也增加，而在右侧颞上回的fALFF降低。在整个样本中发现特定童年创伤严重程度与执行功能障碍和右侧楔前叶的fALFF值之间存在显著相关性。此外，有童年创伤的个体在默认模式网络中与左侧腹内侧前额叶皮层、左侧眶额皮层和右侧小脑基于楔前叶的连接也减少。默认模式网络连接性降低也与童年创伤严重程度和执行功能障碍有关。目前的研究结果表明，即使在健康成年人中，童年创伤也与执行功能缺陷和异常的默认模式网络功能有关。此外，本研究表明执行功能障碍与默认模式网络连接中断有关。
