Büttner D W, Albiez E J, von Essen J, Erichsen J
Department of Helminthology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, FRG.
Trop Med Parasitol. 1988 Dec;39 Suppl 4:390-417.
The methods used for the assessment of adult Onchocerca volvulus by histology are described. Based on the results of several studies, mainly in Liberia and Burkina Faso, the morphology of the adult filariae in histological sections is represented as far as it is relevant for the evaluation. Especially are described the morphological alterations due to old age of the worms, to chronic hyperreactivity of the human host (sowda) and effects of the macrofilaricidal suramin and of microfilaricidal drugs. Quantitative results are reported on untreated adult O. volvulus from various countries, the changes of the worm population during 12 years of vector control in Burkina Faso and the effects of suramin, diethylcarbamazine, metrifonate, and ivermectin. The data from the histological examinations are compared with those gained from the examination of worms isolated by the collagenase technique in the same studies.
本文描述了通过组织学评估成人盘尾丝虫的方法。基于主要在利比里亚和布基纳法索开展的多项研究结果，在组织学切片中呈现了与评估相关的成虫丝虫形态。特别描述了因虫体老化、人类宿主慢性高反应性（sowda）以及杀成虫苏拉明和杀微丝蚴药物所导致的形态学改变。报告了来自不同国家未经治疗的成人盘尾丝虫的定量结果、布基纳法索12年病媒控制期间虫口数量的变化以及苏拉明、乙胺嗪、敌百虫和伊维菌素的效果。将组织学检查的数据与同一研究中通过胶原酶技术分离出的虫体检查所获得的数据进行了比较。
