使用纳米药物递送系统的RNA干扰与抗癌药物的联合治疗方法。
Combinatorial therapeutic approaches with RNAi and anticancer drugs using nanodrug delivery systems.
作者信息
Babu Anish, Munshi Anupama, Ramesh Rajagopal
机构信息
a Department of Pathology , University of Oklahoma Health Sciences Center , Oklahoma City , OK , USA.
b Stephenson Cancer Center, University of Oklahoma Health Sciences Center , Oklahoma City , OK , USA.
出版信息
Drug Dev Ind Pharm. 2017 Sep;43(9):1391-1401. doi: 10.1080/03639045.2017.1313861. Epub 2017 May 19.
Abstract
RNA interference (RNAi) is emerging as a powerful approach in cancer treatment. siRNA is an important RNAi tool that can be designed to specifically silence the expression of genes involved in drug resistance and chemotherapeutic inactivity. Combining siRNA and other therapeutic agents can overcome the multidrug resistance (MDR) phenomenon by simultaneously silencing genes and enhancing chemotherapeutic activity. Moreover, the therapeutic efficiency of anticancer drugs can be significantly improved by additive or synergistic effects induced by siRNA and combined therapies. Co-delivery of these diverse anticancer agents, however, requires specially designed nanocarriers. This review highlights the recent trends in siRNA/anticancer drug co-delivery systems under the major categories of liposomes/lipid, polymeric and inorganic nanoplatforms. The objective is to discuss the strategies for nanocarrier-based co-delivery systems using siRNA/anticancer drug combinations, emphasizing various siRNA targets that help overcome MDR and enhance therapeutic efficiency.
摘要
RNA干扰（RNAi）正逐渐成为癌症治疗中的一种强大方法。小干扰RNA（siRNA）是一种重要的RNAi工具，可设计用于特异性沉默与耐药性和化疗无活性相关的基因表达。将siRNA与其他治疗剂联合使用，可以通过同时沉默基因和增强化疗活性来克服多药耐药（MDR）现象。此外，siRNA和联合疗法诱导的相加或协同效应可显著提高抗癌药物的治疗效率。然而，这些不同抗癌剂的共同递送需要经过特殊设计的纳米载体。本综述重点介绍了脂质体/脂质、聚合物和无机纳米平台等主要类别下siRNA/抗癌药物共递送系统的最新趋势。目的是讨论使用siRNA/抗癌药物组合的基于纳米载体的共递送系统的策略，强调有助于克服MDR和提高治疗效率的各种siRNA靶点。
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