Liu Bo-Na, Gao Xiao-Li, Piao Ying
Department of Oncology, General Hospital of Northern Theater Command, Shenyang 110015, Liaoning Province, China.
World J Gastrointest Oncol. 2024 May 15;16(5):2181-2199. doi: 10.4251/wjgo.v16.i5.2181.
Recent reviews have outlined the main nanomaterials used in relation to gastrointestinal tumors and described the basic properties of these materials. However, the research hotspots and trends in the application of nanomaterials in gastric cancer (GC) remain obscure.
To demonstrate the knowledge structure and evolutionary trends of research into the application of nanomaterials in GC.
Publications related to the application of nanomaterials in GC were retrieved from the Web of Science Core Collection for this systematic review and bibliometric study. VOSviewer and CiteSpace were used for bibliometric and visualization analyses.
From 2000 to 2022, the application of nanomaterials in GC developed rapidly. The keyword co-occurrence analysis showed that the related research topics were divided into three clusters: (1) The application of nanomaterials in GC treatment; (2) The application and toxicity of nanomaterials in GC diagnosis; and (3) The effects of nanomaterials on the biological behavior of GC cells. Complexes, silver nanoparticles, and green synthesis are the latest high-frequency keywords that represent promising future research directions.
The application of nanomaterials in GC diagnosis and treatment and the mechanisms of their effects on GC cells have been major themes in this field over the past 23 years.
近期的综述概述了与胃肠道肿瘤相关的主要纳米材料，并描述了这些材料的基本特性。然而，纳米材料在胃癌（GC）应用中的研究热点和趋势仍不明确。
展示纳米材料在胃癌应用研究的知识结构和演变趋势。
从科学网核心合集检索与纳米材料在胃癌应用相关的出版物，用于本系统综述和文献计量学研究。使用VOSviewer和CiteSpace进行文献计量学和可视化分析。
2000年至2022年，纳米材料在胃癌中的应用发展迅速。关键词共现分析表明，相关研究主题分为三个集群：（1）纳米材料在胃癌治疗中的应用；（2）纳米材料在胃癌诊断中的应用及毒性；（3）纳米材料对胃癌细胞生物学行为的影响。复合物、银纳米颗粒和绿色合成是代表未来有前景研究方向的最新高频关键词。
在过去23年中，纳米材料在胃癌诊断和治疗中的应用及其对胃癌细胞的作用机制一直是该领域的主要主题。
