Rui Marta, Nasti Rita, Bignardi Emanuele, Della Volpe Serena, Rossino Giacomo, Rossi Daniela, Collina Simona
Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Centre for Health Technologies (CHT), Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Pharmaceuticals (Basel). 2017 May 18;10(2):46. doi: 10.3390/ph10020046.
Effective therapies for chronic or non-healing wounds are still lacking. These tissue insults often result in severe clinical complications (i.e., infections and/or amputation) and sometimes lead to patient death. Accordingly, several research groups have focused their efforts in finding innovative and powerful therapeutic strategies to overcome these issues. On the basis of these considerations, the comprehension of the molecular cascades behind these pathological conditions could allow the identification of molecules against chronic wounds. In this context, the regulation of the Protein Kinase C (PKC) cascade has gained relevance in the prevention and/or reparation of tissue damages. This class of phosphorylating enzymes has already been considered for different physiological and pathological pathways and modulation of such enzymes may be useful in reparative processes. Herein, the recent developments in this field will be disclosed, highlighting the pivotal role of PKC α and δ in regenerative medicine. Moreover, an overview of well-established PKC ligands, acting via the modulation of these isoenzymes, will be deeply investigated. This study is aimed at re-evaluating widely known PKC modulators, currently utilized for treating other diseases, as fruitful molecules in wound-healing.
目前仍缺乏针对慢性或难愈合伤口的有效治疗方法。这些组织损伤常常导致严重的临床并发症（如感染和/或截肢），有时甚至会导致患者死亡。因此，几个研究小组致力于寻找创新且有效的治疗策略来解决这些问题。基于这些考虑，了解这些病理状况背后的分子级联反应有助于识别针对慢性伤口的分子。在此背景下，蛋白激酶C（PKC）级联反应的调节在组织损伤的预防和/或修复中变得愈发重要。这类磷酸化酶已被研究用于不同的生理和病理途径，调节此类酶可能对修复过程有益。本文将揭示该领域的最新进展，强调PKCα和δ在再生医学中的关键作用。此外，还将深入研究通过调节这些同工酶起作用的成熟PKC配体。本研究旨在重新评估目前用于治疗其他疾病的广为人知的PKC调节剂，将其作为伤口愈合的有效分子。
