Department of Colorectal Surgery, Tianjin Union Medicine Center, Tianjin, China.
Tianjin Institute of Urology, Department of Urology, Second Hospital of Tianjin Medical University, Tianjin, China.
Cancer Gene Ther. 2017 Jul;24(7):297-303. doi: 10.1038/cgt.2017.17. Epub 2017 May 19.
Frequencies of two glucose transporter 1 (GLUT1) single-nucleotide polymorphisms (SNPs) (XbaI G>T and HaeIII T>C) were studied with urothelial cell carcinomas of the bladder (UCC) and 204 normal persons. And the expression of the p53, Ki67 and GLUT1 was assayed by immunohistochemistry. The frequency of the TT genotype and T allele of the XbaI G>T SNP was decreased in the patients with UCC. The frequency of the CC genotype and C allele of the HaeIII T>C SNP was decreased in the patients with UCC. The GLUT1 XbaI genotype GG was more frequent in higher tumor stage and higher tumor grade patients. In the XbaI G>T SNP, the GG genotype was significantly related to higher Remmele immunoreactive score (IRS) of Ki67 and higher IRS of GLUT1. In conclusion, the TT genotype in XbaI G>T SNP and CC genotype of HaeIII T>C SNP may have protective effect in the carcinogenesis process of UCC. In the XbaI G>T SNP, the GG genotype of was positively related to tumor proliferation, glucose metabolism, tumor grade and stage. Therefore, the variant might become a possible proliferation-related prognostic factor for UCC.
研究了两种葡萄糖转运蛋白 1（GLUT1）单核苷酸多态性（SNP）（XbaI G>T 和 HaeIII T>C）在膀胱尿路上皮细胞癌（UCC）和 204 名正常人中的频率。并通过免疫组织化学检测 p53、Ki67 和 GLUT1 的表达。XbaI G>T SNP 的 TT 基因型和 T 等位基因在 UCC 患者中的频率降低。HaeIII T>C SNP 的 CC 基因型和 C 等位基因在 UCC 患者中的频率降低。GLUT1 XbaI 基因型 GG 在较高肿瘤分期和较高肿瘤分级的患者中更为常见。在 XbaI G>T SNP 中，GG 基因型与 Ki67 的较高 Remmele 免疫反应评分（IRS）和较高 GLUT1 的 IRS 显著相关。总之，XbaI G>T SNP 的 TT 基因型和 HaeIII T>C SNP 的 CC 基因型可能在 UCC 的致癌过程中具有保护作用。在 XbaI G>T SNP 中，GG 基因型与肿瘤增殖、葡萄糖代谢、肿瘤分级和分期呈正相关。因此，该变体可能成为 UCC 的一种潜在增殖相关预后因素。
