The Effect of GLUT-1-XbaI G>T and HaeIII T>C Polymorphisms on F-FDG Uptake Rates.

OBJECTIVES

To investigate the effects of glut polymorphisms on Fluorine-fluorodeoxyglucose (F-FDG) uptake rates.

METHODS

The F-FDG positron emission tomography/computed tomography images and mass lesion metabolism standard uptake value maximum (SUV) results of the patients were evaluated. Glucose transporter protein-1 (GLUT-1)-XbaI G>T (rs2754218) and HaeIII T>C (rs1385129) polymorphisms and their effects on F-FDG uptake rates were investigated using DNA obtained from peripheral blood.

RESULTS

When the Xbal G>T genotype distribution of the patients was examined, the Xbal G/G genotype was found to be 87%, the Xbal G/T genotype 12%. The XbaI T/T phenotype was detected in only one patient (1%). In the HaeIII T>C genotype distribution, the HaeIII C/C genotype was found as 54%, the HaeIII T/C genotype as 31%, and the HaeIII T/T genotype as 15%. When the Xbal and HaeIII genotypes were examined together, the number of polymorphic genotypes was significantly higher in the lung and bronchial tumor groups compared to other cancer types.

CONCLUSION

The presence of polymorphism in at least one of the two gene regions, in the lung-bronchial tumor group and the high SUV value in this patient group, may indicate a change in the involvement rates.