Kısaarslan Melih, Adalı Yasemin, Aydın Veli Kaan, Berberoğlu Yasemin, Yüksel Doğangün, Köseler Aylin
Pamukkale University Faculty of Medicine, Department of Biophysics, Denizli, Türkiye.
Pamukkale University Faculty of Medicine, Department of Nuclear Medicine, Denizli, Türkiye.
Mol Imaging Radionucl Ther. 2025 Jun 3;34(2):90-96. doi: 10.4274/mirt.galenos.2025.93797.
To investigate the effects of glut polymorphisms on Fluorine-fluorodeoxyglucose (F-FDG) uptake rates.
The F-FDG positron emission tomography/computed tomography images and mass lesion metabolism standard uptake value maximum (SUV) results of the patients were evaluated. Glucose transporter protein-1 (GLUT-1)-XbaI G>T (rs2754218) and HaeIII T>C (rs1385129) polymorphisms and their effects on F-FDG uptake rates were investigated using DNA obtained from peripheral blood.
When the Xbal G>T genotype distribution of the patients was examined, the Xbal G/G genotype was found to be 87%, the Xbal G/T genotype 12%. The XbaI T/T phenotype was detected in only one patient (1%). In the HaeIII T>C genotype distribution, the HaeIII C/C genotype was found as 54%, the HaeIII T/C genotype as 31%, and the HaeIII T/T genotype as 15%. When the Xbal and HaeIII genotypes were examined together, the number of polymorphic genotypes was significantly higher in the lung and bronchial tumor groups compared to other cancer types.
The presence of polymorphism in at least one of the two gene regions, in the lung-bronchial tumor group and the high SUV value in this patient group, may indicate a change in the involvement rates.
研究谷氨酰胺多态性对氟代脱氧葡萄糖（F-FDG）摄取率的影响。
评估患者的F-FDG正电子发射断层扫描/计算机断层扫描图像及肿块代谢标准摄取值最大值（SUV）结果。利用外周血提取的DNA研究葡萄糖转运蛋白-1（GLUT-1）的XbaI G>T（rs2754218）和HaeIII T>C（rs1385129）多态性及其对F-FDG摄取率的影响。
检查患者的Xbal G>T基因型分布时，发现Xbal G/G基因型占87%，Xbal G/T基因型占12%。仅在1例患者（1%）中检测到XbaI T/T表型。在HaeIII T>C基因型分布中，发现HaeIII C/C基因型占54%，HaeIII T/C基因型占31%，HaeIII T/T基因型占15%。同时检查Xbal和HaeIII基因型时，与其他癌症类型相比，肺和支气管肿瘤组的多态基因型数量显著更高。
肺-支气管肿瘤组两个基因区域中至少一个存在多态性，且该患者组SUV值较高，这可能表明参与率发生了变化。
