McDaniel Dalton, Tilton Emily, Dominick Kathryn, Flory Kale, Ernest Taylor, Johnson Jane C, Main Donet C, Kondrashov Peter
Kirksville College of Osteopathic Medicine, A.T. Still University, Kirksville, Missouri.
A.T. Still Research Institute, A.T. Still University, Kirksville, Missouri.
Clin Anat. 2017 Sep;30(6):805-810. doi: 10.1002/ca.22920. Epub 2017 Jun 15.
Existing data indicate knee menisci in patients with osteoarthritis (OA) show tearing, maceration, and fragmentation, but little is known about the change in histological structure. The aim of this study was to evaluate the change in the menisci histological structure in patients with clinically diagnosed knee OA. Fourteen patients undergoing surgical treatment of knee OA (OA group) and 14 cadaveric knees (control group) were assessed. Demographic data, medical history, synovial fluid, OA severity, medial meniscus (MM) tissue, and lateral meniscus (LM) tissue were collected from the OA group. Three nonconsecutive 10 μm cross-sectional tissue slices of menisci were analyzed for percentage of tissue calcification. Exact Mann-Whitney tests and Spearman correlation coefficients tested for relationships between variables. The major change in the histological structure of the menisci in patients with OA was calcification of the matrix, which was significantly greater in the OA group compared with the control group for MM (OA: 11.9%, cadaver: 5.17%; P < 0.001) and LM tissues (OA: 11.1%, cadaver: 4.2%; P < 0.001). A correlation between percent calcification of the MM and LM tissues existed in the OA group (ρ = 0.56, P = 0.04) but not the control group (P = 0.20). The most pronounced pathological change in the histology of menisci was calcification of the cartilage matrix, significantly greater in the OA group than the control group. A strong correlation between percent calcification of MM and LM tissues in patients with OA indicates changes in fibrocartilage matrix of menisci progress similarly in the medial and lateral compartments of the knee. Clin. Anat. 30:805-810, 2017. © 2017Wiley Periodicals, Inc.
现有数据表明，骨关节炎（OA）患者的膝关节半月板会出现撕裂、浸软和碎裂，但对于其组织结构变化却知之甚少。本研究旨在评估临床诊断为膝关节OA患者半月板组织结构的变化。对14例行膝关节OA手术治疗的患者（OA组）和14个尸体膝关节（对照组）进行了评估。收集了OA组的人口统计学数据、病史、滑液、OA严重程度、内侧半月板（MM）组织和外侧半月板（LM）组织。对半月板的三个非连续10μm横截面组织切片进行组织钙化百分比分析。采用精确曼-惠特尼检验和斯皮尔曼相关系数检验变量之间的关系。OA患者半月板组织结构的主要变化是基质钙化，MM（OA组：11.9%，尸体组：5.17%；P<0.001）和LM组织（OA组：11.1%，尸体组：4.2%；P<0.001）的钙化在OA组显著高于对照组。OA组MM和LM组织的钙化百分比之间存在相关性（ρ=0.56，P=0.04），而对照组不存在相关性（P=0.20）。半月板组织学中最明显的病理变化是软骨基质钙化，OA组明显大于对照组。OA患者MM和LM组织钙化百分比之间的强相关性表明，半月板纤维软骨基质的变化在膝关节内侧和外侧间室中进展相似。《临床解剖学》30:805 - 810，2017年。©2017威利期刊公司
