Aslani Saeed, Mahmoudi Mahdi, Salmaninejad Arash, Poursani Shiva, Ziaee Vahid, Rezaei Nima
a Rheumatology Research Center , Tehran University of Medical Sciences , Tehran , Iran.
b Department of Immunology, School of Medicine , Tehran University of Medical Sciences , Tehran , Iran.
Fetal Pediatr Pathol. 2017 Jun;36(3):177-183. doi: 10.1080/15513815.2016.1253809. Epub 2017 Mar 2.
Juvenile rheumatoid arthritis (JRA) is a common chronic systemic autoimmune disease in children. Single nucleotide polymorphisms (SNPs) of signal transducer and activator of transcription 4 (STAT4) gene are suspected to have association with the risk of autoimmune diseases. Previous investigations have indicated that the STAT4 rs7574865 T allele was significantly associated with rheumatoid arthritis. In this study, we aimed to evaluate the association of STAT4 SNPs with JRA in Iranian population. T allele of STAT4 rs7574865 SNP was less frequent in patients than in controls, and the difference was not significant (p = 0.19, OR = 0.72, 95% CI: 0.44 -1.17). In addition, G allele of this SNP was frequent but not significant in JRA patients (p = 0.19, OR = 1.38, 95% CI: 0.85-2.25). Neither alleles nor genotypes of rs7601754 SNP of STAT4 gene demonstrated associations with JRA. We recognize that gene variants of STAT4 did not affect JRA susceptibility in Iranian population.
青少年类风湿性关节炎（JRA）是儿童常见的慢性全身性自身免疫性疾病。信号转导和转录激活因子4（STAT4）基因的单核苷酸多态性（SNP）被怀疑与自身免疫性疾病的风险有关。先前的研究表明，STAT4 rs7574865 T等位基因与类风湿性关节炎显著相关。在本研究中，我们旨在评估伊朗人群中STAT4 SNP与JRA的关联。STAT4 rs7574865 SNP的T等位基因在患者中的频率低于对照组，差异无统计学意义（p = 0.19，OR = 0.72，95% CI：0.44 - 1.17）。此外，该SNP的G等位基因在JRA患者中频率较高，但差异无统计学意义（p = 0.19，OR = 1.38，95% CI：0.85 - 2.25）。STAT4基因rs7601754 SNP的等位基因和基因型均未显示与JRA有关联。我们认识到，在伊朗人群中，STAT4的基因变异不会影响JRA易感性。
