Bernatsky Sasha, Smargiassi Audrey, Joseph Lawrence, Awadalla Phillip, Colmegna Ines, Hudson Marie, Fritzler Marvin J
Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, 687 Pine Avenue West, V-Building (V2.09), Montreal, Canada H3A 1A1.
Département de santé environnementale et de santé au travail, Université de Montréal, Pavillon Marguerite d'Youville, École de santé publique, Montréal, QC, Canada; Institut National de Santé Publique du Québec, Montréal, QC, Canada.
Environ Res. 2017 Aug;157:60-63. doi: 10.1016/j.envres.2017.04.035. Epub 2017 May 17.
To determine the association of anti-citrullinated antibodies (ACPA) with the ambient air pollutants fine particulate matter (PM2.5) and sulfur dioxide (SO2).
The CARTaGENE first-wave cohort includes 20,000 general population subjects from Quebec (Canada). On a sample of unselected 1586 subjects, we determined serum, ACPA and performed multivariable logistic regression, for the outcome of positive ACPA, assessing for independent effects of our air pollution variables, adjusting for age, sex, smoking, and French Canadian origin. Two models assessed distance to main industrial emitters of PM, and of SO2, and two models assessed tons of SO2 and of PM annual emissions. We also assessed associations with PM2.5 regional ambient concentrations estimated with satellite imagery.
Adjusted analyses suggested a positive association between annual industrial PM and SO2 emissions and the presence of ACPA antibodies (OR: 1.02, 95%CI 1.00-1.04 per 10t of PM2.5 and 100t of SO2). The data were also consistent with a negative association between the presence of ACPA, and distance to a major industrial emitter of both PM and SO. We found no association with PM2.5 estimates of ambient levels.
These analyses suggest that exposure to industrial emissions of air pollutants is related to ACPA positivity.
确定抗瓜氨酸化抗体（ACPA）与环境空气污染物细颗粒物（PM2.5）和二氧化硫（SO2）之间的关联。
CARTaGENE首波队列包括来自加拿大魁北克的20000名普通人群受试者。在1586名未经过筛选的受试者样本中，我们检测了血清ACPA，并进行多变量逻辑回归分析，以ACPA阳性为结果，评估空气污染变量的独立影响，并对年龄、性别、吸烟情况和法裔加拿大血统进行校正。两个模型评估了距PM主要工业排放源和SO2主要工业排放源的距离，另外两个模型评估了SO2和PM的年度排放量。我们还评估了与通过卫星图像估算的PM2.5区域环境浓度之间的关联。
校正分析表明，年度工业PM和SO2排放量与ACPA抗体的存在呈正相关（每10吨PM2.5和100吨SO2的比值比：1.02，95%置信区间1.00 - 1.04）。数据还表明ACPA的存在与距PM和SO主要工业排放源的距离呈负相关。我们未发现与环境水平的PM2.5估算值存在关联。
这些分析表明，暴露于空气污染物的工业排放与ACPA阳性有关。
