Ruan Xiulu, Mancuso Ken F, Kaye Alan D
Department of Anesthesiology, Louisiana State University Health Science Center, 1542 Tulane Avenue, New Orleans, LA 70112, USA.
Department of Anesthesiology, Louisiana State University Health Science Center, 1542 Tulane Avenue, New Orleans, LA 70112, USA.
Anesthesiol Clin. 2017 Jun;35(2):e163-e174. doi: 10.1016/j.anclin.2017.01.022. Epub 2017 Mar 14.
Oxycodone, a semisynthetic opioid analgesic, is widely used in clinical practice. Oxycodone and morphine seem to be equally effective and equipotent; however, morphine is 10 times more potent than oxycodone when given epidurally. This article provides an updated review of the basic pharmacology of oxycodone with a special focus on pharmacokinetic/pharmacodynamics properties. The controversy regarding oxycodone-mediated effects for visceral pain via agonism and the possible role of peripheral opioid analgesia are discussed in the present investigation in an attempt to propose a plausible explanation to the perplexing question of oxycodone analgesia.
羟考酮是一种半合成阿片类镇痛药，在临床实践中广泛应用。羟考酮和吗啡似乎具有同等疗效和效价；然而，硬膜外给药时，吗啡的效价比羟考酮强10倍。本文对羟考酮的基础药理学进行了更新综述，特别关注其药代动力学/药效学特性。本研究讨论了关于羟考酮通过激动作用介导内脏痛效应的争议以及外周阿片类镇痛的可能作用，试图对羟考酮镇痛这一令人困惑的问题提出合理的解释。
