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Genomics of Posttraumatic Stress Disorder: Sequencing Stress and Modeling Misfortune.

作者信息

Stein Murray B

机构信息

Department of Psychiatry and Family Medicine and Public Health, University of California San Diego, San Diego, California; Psychiatry Service, VA San Diego Healthcare System, San Diego, California.

出版信息

Biol Psychiatry. 2018 May 15;83(10):795-796. doi: 10.1016/j.biopsych.2017.05.001. Epub 2017 May 5.

DOI:10.1016/j.biopsych.2017.05.001
PMID:28526398
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7000225/
Abstract
摘要

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Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability.最大规模的创伤后应激障碍全基因组关联研究（N=20070）显示遗传与精神分裂症重叠，并存在遗传可变性的性别差异。
Mol Psychiatry. 2018 Mar;23(3):666-673. doi: 10.1038/mp.2017.77. Epub 2017 Apr 25.
2
The Genetics and Epigenetics of PTSD: Overview, Recent Advances, and Future Directions.创伤后应激障碍的遗传学与表观遗传学：概述、最新进展及未来方向
Curr Opin Psychol. 2017 Apr;14:5-11. doi: 10.1016/j.copsyc.2016.09.003.
3
Polygenic Epidemiology.多基因流行病学
Genet Epidemiol. 2016 May;40(4):268-72. doi: 10.1002/gepi.21966. Epub 2016 Apr 7.
4
636,120 Ways to Have Posttraumatic Stress Disorder.636120 种创伤后应激障碍的方式。
Perspect Psychol Sci. 2013 Nov;8(6):651-62. doi: 10.1177/1745691613504115.
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Epidemiology of posttraumatic stress disorder: prevalence, correlates and consequences.创伤后应激障碍的流行病学：患病率、相关因素及后果。
Curr Opin Psychiatry. 2015 Jul;28(4):307-11. doi: 10.1097/YCO.0000000000000167.
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Dimensional structure of DSM-5 posttraumatic stress disorder symptoms: results from the National Health and Resilience in Veterans Study.DSM-5 创伤后应激障碍症状的维度结构：来自国家健康和退伍军人适应力研究的结果。
J Clin Psychiatry. 2015 May;76(5):546-53. doi: 10.4088/JCP.14m09091.
7
Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions.等位基因特异性 FKBP5 DNA 去甲基化介导基因-儿童期创伤的相互作用。
Nat Neurosci. 2013 Jan;16(1):33-41. doi: 10.1038/nn.3275. Epub 2012 Dec 2.
8
The Covariate's Dilemma.协变量的困境
PLoS Genet. 2012;8(11):e1003096. doi: 10.1371/journal.pgen.1003096. Epub 2012 Nov 8.
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Twin studies of posttraumatic stress disorder: differentiating vulnerability factors from sequelae.创伤后应激障碍的双胞胎研究：区分易感性因素和后遗症。
Neuropharmacology. 2012 Feb;62(2):647-53. doi: 10.1016/j.neuropharm.2011.03.012. Epub 2011 Mar 31.
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Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults.FKBP5基因多态性与童年期虐待经历和成年人创伤后应激障碍症状风险的关联。
JAMA. 2008 Mar 19;299(11):1291-305. doi: 10.1001/jama.299.11.1291.