Laboratory for Traumatic Stress Studies, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, 100049, China.
Laboratory for Traumatic Stress Studies, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, 100049, China.
Chin J Traumatol. 2021 Jul;24(4):209-213. doi: 10.1016/j.cjtee.2021.03.007. Epub 2021 Mar 28.
Evidence suggests that the oxytocin receptor (OXTR) gene may be involved in the psychopathology of posttraumatic stress disorder (PTSD). This study aimed to investigate the effects of OXTR rs53576 genotype on PTSD symptoms introduced in the Diagnostic and Statistical Manual, Fifth Edition (DSM-5).
This study was a cross-sectional study conducted among 1140 adults who had personally experienced the Wenchuan earthquake. PTSD symptoms were measured with the PTSD checklist for DSM-5. A custom-by-design 2 × 48-Plex SNPscan Kit were used to determine the OXTR rs53576. Multiple regression models were used to analyze the independent and interactive effects of OXTR rs53576 genotype and earthquake exposure on the severity of total PTSD symptoms and different dimensions of PTSD symptoms.
The results revealed that the rs53576 genotype could significantly predict PTSD symptoms (β = 0.055, p = 0.045). Further analysis showed that the rs53576 genotype was only significantly associated with dysphoric arousal symptoms of PTSD (β = 0.080, p = 0.005). The rs53576 genotype × earthquake exposure interaction had no significant effect on different symptom clusters (p > 0.05).
This study showed that the rs53576 genotype was only associated with the dysphoric arousal symptoms but not with other symptom clusters of PTSD. These findings support the role of the OXTR on the psychopathology of PTSD and help us to understand the genetic basis of PTSD.
有证据表明，催产素受体（OXTR）基因可能与创伤后应激障碍（PTSD）的精神病理学有关。本研究旨在探讨 OXTR rs53576 基因型对第五版《精神疾病诊断与统计手册》（DSM-5）中引入的 PTSD 症状的影响。
这是一项横断面研究，共纳入 1140 名曾亲身经历汶川地震的成年人。采用 PTSD 检查表 DSM-5 测量 PTSD 症状。使用定制的 2×48-Plex SNPscan 试剂盒确定 OXTR rs53576。采用多元回归模型分析 OXTR rs53576 基因型与地震暴露对 PTSD 总症状严重程度和 PTSD 不同维度症状的独立和交互作用。
结果表明，rs53576 基因型可显著预测 PTSD 症状（β=0.055，p=0.045）。进一步分析显示，rs53576 基因型仅与 PTSD 的苦恼激惹症状显著相关（β=0.080，p=0.005）。rs53576 基因型×地震暴露的交互作用对不同症状簇无显著影响（p>0.05）。
本研究表明，rs53576 基因型仅与苦恼激惹症状相关，而与 PTSD 的其他症状簇无关。这些发现支持 OXTR 在 PTSD 精神病理学中的作用，并帮助我们了解 PTSD 的遗传基础。
