Abeler V, Kjørstad K E, Nesland J M
Department of Pathology, Norwegian Radium Hospital, Oslo.
Int J Gynecol Pathol. 1988;7(4):315-29. doi: 10.1097/00004347-198812000-00003.
Six cases of small cell carcinoma of the ovary are presented. The tumors occurred in women with an average age of 27.5 years. According to the International Federation of Gynecology and Obstetrics (FIGO), two patients had Stage I, three Stage II, and one Stage III disease. The tumors behaved highly malignantly, as four of the patients died from disseminated disease within 20 months. Three of the tumors were found to be associated with elevated serum calcium levels. By light microscopy three of the tumors were originally misinterpreted: one as an undifferentiated tumor, probably of stromal origin; one as a germ cell tumor, probably endodermal sinus tumor; and the third as a granulosa cell tumor. In four tumors examined by electron microscopy, the epithelial nature was confirmed, and three of them contained neuroendocrine granules. Immunocytochemical examination in five cases revealed positive staining for neuron-specific enolase (NSE) and negative staining for beta 2-microglobulin, whereas one case was negative for NSE and positive for beta 2-microglobulin. A positive immunoreaction for parathyroid hormone was observed in three cases (all NSE positive). In two of these a raised serum calcium level was documented. This finding possibly gives a clue to the hypercalcemia so frequently found in these patients.
本文报告6例卵巢小细胞癌。肿瘤发生于平均年龄27.5岁的女性。根据国际妇产科联盟（FIGO）分期，2例为Ⅰ期，3例为Ⅱ期，1例为Ⅲ期。肿瘤具有高度恶性，4例患者在20个月内死于播散性疾病。3例肿瘤发现血清钙水平升高。光镜检查时，3例肿瘤最初被误诊：1例误诊为可能起源于基质的未分化肿瘤；1例误诊为可能是内胚窦瘤的生殖细胞肿瘤；第3例误诊为颗粒细胞瘤。在4例接受电镜检查的肿瘤中，证实为上皮性肿瘤，其中3例含有神经内分泌颗粒。5例免疫细胞化学检查显示神经元特异性烯醇化酶（NSE）染色阳性，β2-微球蛋白染色阴性，而1例NSE染色阴性，β2-微球蛋白染色阳性。3例（均为NSE阳性）观察到甲状旁腺激素免疫反应阳性。其中2例记录到血清钙水平升高。这一发现可能为这些患者中经常出现的高钙血症提供了线索。
