Itonaga Yui, Nishida Masakazu, Matsumoto Harunobu, Nasu Kaei, Narahara Hisashi
Department of Obstetrics and Gynecology, Faculty of Medicine Oita University, Oita, Japan.
Rare Tumors. 2017 Jul 3;9(2):6958. doi: 10.4081/rt.2017.6958.
Neuroendocrine carcinoma (NEC), also called small cell carcinoma or large cell carcinoma, is a rare and aggressive tumor that develops mainly in the lung and intestine. More rarely, NEC develops in gynecologic organs, with poor prognoses. We experienced a case of NEC in the broad ligament of the uterus. The patient was a 74-year-old woman with symptoms of abdominal distension and constipation. Ultrasound sonography detected an abdominal tumor larger than 10 cm. She was then admitted to our hospital. She underwent surgery under the diagnosis of ovarian cancer, but the bilateral ovaries and uterus were normal in appearance, and a tumor was developing instead from the broad ligament of the uterus. The patient then received a hysterectomy, salpingo-oophorectomies, and lymphadenectomy, and the peritoneal membrane was stripped around the pelvic space. Despite our suggestion, she never accepted the adjuvant treatment. She discontinued her periodic follow-up with and was followed in another hospital. Generally, the prognosis of NEC is poor, and there is no established treatment for a tumor in a gynecologic lesion. However, we anticipate that the accumulation of experience treating such cases will eventually lead to a standard treatment for NEC.
神经内分泌癌（NEC），也称为小细胞癌或大细胞癌，是一种罕见的侵袭性肿瘤，主要发生在肺和肠道。更罕见的是，NEC发生于妇科器官，预后较差。我们遇到了一例发生在子宫阔韧带的NEC病例。患者为一名74岁女性，有腹胀和便秘症状。超声检查发现一个大于10厘米的腹部肿瘤。随后她入住我院。她在诊断为卵巢癌的情况下接受了手术，但双侧卵巢和子宫外观正常，肿瘤是从子宫阔韧带处生长出来的。患者随后接受了子宫切除术、输卵管卵巢切除术和淋巴结切除术，并在盆腔周围剥离了腹膜。尽管我们提出了建议，但她从未接受辅助治疗。她中断了定期随访，后来在另一家医院接受随访。一般来说，NEC的预后较差，对于妇科病变中的肿瘤尚无既定的治疗方法。然而，我们预计积累治疗此类病例的经验最终将导致NEC的标准化治疗。
