Peng Xue, Wang Hongjing
Department of Obstetrics and Gynecology, West China Second Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
Medicine (Baltimore). 2020 Dec 4;99(49):e22474. doi: 10.1097/MD.0000000000022474.
Ovarian large cell neuroendocrine carcinoma (LCNEC), or ovarian non-small cell neuroendocrine carcinoma, which is a newly described tumour in the classification of primary ovarian neoplasms by the World Health Organization, is a rare entity that is frequently associated with a surface epithelial and germ cell neoplasm component. Few cases have been reported in the literature, and only 18 primary pure ovarian LCNEC cases have been reported so far, including our 1 case. Ovarian LCNEC is a highly aggressive tumor with a poor prognosis even at an early stage.
We report a case of a 55-year-old postmenopausal woman who complained of abdominal pain. CT examination revealed a mass in the right adnexial region and CA125 level was elevated.
She underwent a exploratory laparotomy, and diagnosed as LCNEC histopathologically.
Cytoreductive surgery was administered to the patient, and had accepted 5 cycles of chemotherapy consisting of paclitaxel and cisplatin.
Follow-up for 12 months showed no clinical or radiological evidence of disease recurrence.
This case is 1 of the ovarian LCNEC which is a rare and extremely malignant tumor. Diagnosis requires histopathology and immunohistochemistry. The treatment includes primary cytoreductive surgery followed by chemotherapy.
卵巢大细胞神经内分泌癌（LCNEC），即卵巢非小细胞神经内分泌癌，是世界卫生组织在原发性卵巢肿瘤分类中新描述的一种肿瘤，是一种罕见的实体瘤，常与表面上皮和生殖细胞肿瘤成分相关。文献报道的病例很少，迄今为止仅报道了18例原发性纯卵巢LCNEC病例，包括我们报道的1例。卵巢LCNEC是一种侵袭性很强的肿瘤，即使在早期预后也很差。
我们报告1例55岁绝经后女性，主诉腹痛。CT检查发现右附件区有一肿块，CA125水平升高。
她接受了剖腹探查术，病理组织学诊断为LCNEC。
对患者实施了肿瘤细胞减灭术，并接受了5个周期由紫杉醇和顺铂组成的化疗。
随访12个月，未发现疾病复发的临床或影像学证据。
该病例是卵巢LCNEC之一，这是一种罕见且恶性程度极高的肿瘤。诊断需要病理组织学和免疫组织化学检查。治疗包括原发性肿瘤细胞减灭术，随后进行化疗。
