Nano Carbon Materials Research Lab, Istituto Italiano di Tecnologia (IIT), Via Morego 30, 16163 Genova, Italy.
Coimbra Chemistry Centre, Dept. of Chemistry, University of Coimbra, Rua Larga, Coimbra, Portugal.
Adv Colloid Interface Sci. 2017 Nov;249:163-180. doi: 10.1016/j.cis.2017.05.009. Epub 2017 May 9.
Over the past ten years, the global biopharmaceutical market has remarkably grown, with ten over the top twenty worldwide high performance medical treatment sales being biologics. Thus, biotech R&D (research and development) sector is becoming a key leading branch, with expanding revenues. Biotechnology offers considerable advantages compared to traditional therapeutic approaches, such as reducing side effects, specific treatments, higher patient compliance and therefore more effective treatments leading to lower healthcare costs. Within this sector, smart nanotechnology and colloidal self-assembling systems represent pivotal tools able to modulate the delivery of therapeutics. A comprehensive understanding of the processes involved in the self-assembly of the colloidal structures discussed therein is essential for the development of relevant biomedical applications. In this review we report the most promising and best performing platforms for specific classes of bioactive molecules and related target, spanning from siRNAs, gene/plasmids, proteins/growth factors, small synthetic therapeutics and bioimaging probes.
在过去的十年中，全球生物制药市场显著增长，全球前二十大销售额最高的药品中有十种是生物制剂。因此，生物技术研发（R&D）部门正成为一个关键的主导分支，收入不断扩大。与传统的治疗方法相比，生物技术具有相当大的优势，例如减少副作用、针对性治疗、更高的患者依从性，从而使治疗效果更有效，降低医疗保健成本。在这个领域，智能纳米技术和胶体自组装系统是能够调节治疗药物输送的关键工具。全面了解胶体结构自组装过程对于开发相关的生物医学应用至关重要。在这篇综述中，我们报告了最有前途和表现最好的用于特定类别的生物活性分子和相关靶标的平台，涵盖了 siRNA、基因/质粒、蛋白质/生长因子、小分子治疗药物和生物成像探针。
