Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Cell. 2022 Jul 21;185(15):2770-2788. doi: 10.1016/j.cell.2022.06.035. Epub 2022 Jul 13.
Cancer vaccines aim to direct the immune system to eradicate cancer cells. Here we review the essential immunologic concepts underpinning natural immunity and highlight the multiple unique challenges faced by vaccines targeting cancer. Recent technological advances in mass spectrometry, neoantigen prediction, genetically and pharmacologically engineered mouse models, and single-cell omics have revealed new biology, which can help to bridge this divide. We particularly focus on translationally relevant aspects, such as antigen selection and delivery and the monitoring of human post-vaccination responses, and encourage more aggressive exploration of novel approaches.
癌症疫苗旨在引导免疫系统消灭癌细胞。在这里，我们回顾了自然免疫的基本免疫学概念，并强调了针对癌症的疫苗所面临的多个独特挑战。近年来，质谱、新抗原预测、基因和药理学工程小鼠模型以及单细胞组学等技术的进步揭示了新的生物学知识，这有助于弥合这一鸿沟。我们特别关注转化相关的方面，如抗原选择和传递以及人类接种疫苗后的反应监测，并鼓励更积极地探索新方法。
