Li Xian-Bin, Bo Qi-Jing, Zhang Guang-Ping, Zheng Wei, Wang Zhi-Min, Li An-Ning, Tian Qing, Liu Jin-Tong, Tang Yi-Lang, Wang Chuan-Yue
Beijing Key Laboratory of Mental Disorders, Beijing Institute for Brain Disorders Center of Schizophrenia, Laboratory of Brain Disorders (Ministry of Science and Technology), Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China.
The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
Compr Psychiatry. 2017 Jul;76:147-152. doi: 10.1016/j.comppsych.2017.04.010. Epub 2017 May 5.
In this study, we aimed to determine the influence of various types of childhood trauma (CT) on cognitive functions in Chinese patients presented with schizophrenia. One hundred sixty-two patients were assessed with the Childhood Trauma Questionnaire-Short Form (CTQ-SF) and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). We investigated the correlations between various types of CT, demographic characteristics, and cognitive functions. Significant negative correlations were observed in physical abuse (PA) and sexual abuse (SA) with the language score (r=-0.190, -0.216, respectively, p<0.05). Similarly, physical neglect (PN) and the total score of CTQ were negatively correlated with the attention score (r=-0.17, -0.206, p<0.05, respectively) as well as the total RBANS score (r=-0.199, -0.223, respectively P<0.05). PN was also negatively correlated with delayed memory (r=-0.167, p<0.05). Regressions analysis indicated significant negative correlations between PN and attention, as well as the cognitive total score (p<0.001). Furthermore, demographic variables (years of education, family income) and clinical characteristics (type of anti-psychotics, duration of illness and times of recurrence) were correlated with cognitive functions. The current study showed that different types of CT could impact specific cognitive functions in Chinese schizophrenia patients. Therefore, we recommend that trauma-focused mental interventions for schizophrenia patients should be developed and routinely offered to patients.
在本研究中，我们旨在确定各类童年创伤（CT）对患有精神分裂症的中国患者认知功能的影响。162名患者接受了儿童创伤问卷简表（CTQ-SF）和可重复使用的神经心理状态评估量表（RBANS）评估。我们调查了各类CT、人口统计学特征与认知功能之间的相关性。身体虐待（PA）和性虐待（SA）与语言得分呈显著负相关（分别为r = -0.190、-0.216，p < 0.05）。同样，身体忽视（PN）和CTQ总分与注意力得分呈负相关（分别为r = -0.17、-0.206，p < 0.05）以及RBANS总分呈负相关（分别为r = -0.199、-0.223，P < 0.05）。PN与延迟记忆也呈负相关（r = -0.167，p < 0.05）。回归分析表明PN与注意力以及认知总分之间存在显著负相关（p < 0.001）。此外，人口统计学变量（受教育年限、家庭收入）和临床特征（抗精神病药物类型、病程和复发次数）与认知功能相关。当前研究表明，不同类型的CT可能会影响中国精神分裂症患者的特定认知功能。因此，我们建议应为精神分裂症患者制定并常规提供以创伤为重点的心理干预措施。
