中国男性受试者的 CSF 乳酸水平与 MoCA 评分呈负相关。
Negative correlation between CSF lactate levels and MoCA scores in male Chinese subjects.
机构信息
Department of Pathology, Xinxiang Medical University, Xinxiang 453003, China.
College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.
出版信息
Psychiatry Res. 2017 Sep;255:49-51. doi: 10.1016/j.psychres.2017.05.017. Epub 2017 May 12.
Lactate is a product of glycolysis by astrocytes and can be generated as a primary metabolic energy source by neurons. Lactate plays multifunctional role in human brain energy metabolism and cognitive function. However, no direct evidence demonstrated the link between lactate and cognition in normal condition. In the present study, concentrations of lactate in cerebrospinal fluid (CSF) and peripheral blood were measured to investigate the association of lactate with cognitive ability, which was assessed by Montreal Cognitive Assessment (MoCA), in 99 male Chinese subjects. Correlation analyses revealed that serum lactate levels were negatively correlated with age, and CSF lactate levels were negatively correlated with MoCA scores after Box-Cox transformations. But no correlation was found between serum lactate levels and MoCA scores after Box-Cox transformations. In conclusion, the results indicate that CSF lactate levels were negatively correlated with MoCA scores in male Chinese subjects.
乳酸是星形胶质细胞糖酵解的产物，可作为神经元的主要代谢能源产生。乳酸在人类大脑能量代谢和认知功能中具有多种功能。然而，目前还没有直接的证据表明在正常情况下乳酸与认知之间存在联系。在本研究中，我们测量了 99 名中国男性受试者的脑脊液（CSF）和外周血中的乳酸浓度，以探讨乳酸与认知能力之间的关系，认知能力通过蒙特利尔认知评估（MoCA）进行评估。相关性分析显示，血清乳酸水平与年龄呈负相关，经 Box-Cox 变换后 CSF 乳酸水平与 MoCA 评分呈负相关。但是，经 Box-Cox 变换后，血清乳酸水平与 MoCA 评分之间未发现相关性。总之，这些结果表明，在中国男性受试者中，CSF 乳酸水平与 MoCA 评分呈负相关。
Zotero 插件