健康马和小马里 l-乳酸和葡萄糖浓度与体况评分的相关性。
Correlation between l-lactate and glucose concentrations and body condition score in healthy horses and ponies.
机构信息
Department of Clinical Science and Services, The Royal Veterinary College, North Mymms, United Kingdom.
Research Support Office, The Royal Veterinary College, North Mymms, United Kingdom.
出版信息
J Vet Intern Med. 2019 Sep;33(5):2267-2271. doi: 10.1111/jvim.15587. Epub 2019 Aug 7.
BACKGROUND
Blood l-lactate and glucose concentrations were higher in ponies with gastrointestinal disease than in horses, possibly because of differences in body condition (BC).
OBJECTIVES
To investigate whether l-lactate and glucose concentrations correlate with BC and differ between healthy horses and ponies.
ANIMALS
Systemically healthy client-owned ponies (n = 101) and horses (n = 51).
METHODS
Prospective observational study. Breed, weight, height, and subjective and objective measures of BC were recorded and l-lactate and glucose concentrations were measured. Correlations between l-lactate and glucose concentrations and BC were established. The association between l-lactate concentrations, equid type (pony or horse), BC, age, and glucose concentrations was investigated using a multivariable model.
RESULTS
Weak but significant (P = .001) negative correlations were detected between l-lactate concentration and average BC score (r = -0.29), heart girth:height ratio (r = -0.27), and age (r = -0.27). Glucose concentrations were significantly (P < .001) positively correlated with neck length:heart girth ratio (r = 0.37) and heart girth:height ratio (r = 0.31). l-lactate and glucose concentrations were weakly correlated (r = 0.15; P = .04). In the final multivariable model, age (-0.02 ± 0.006; P = .001) and heart girth:height ratio (-1.74 ± 0.53; P = .001) were significantly associated with the natural logarithm of l-lactate concentration (Lnl-Lactate). This represents a 2% decrease in l-lactate concentration per year increase in age and 10% decrease in l-lactate concentration per 0.06 unit increase in heart girth:height ratio.
CONCLUSIONS AND CLINICAL IMPORTANCE
In healthy horses and ponies, age and BC significantly influence l-lactate concentrations.
背景
患有胃肠道疾病的小马血液中 l-乳酸和葡萄糖浓度高于马，这可能是由于体况（BC）的差异。
目的
研究 l-乳酸和葡萄糖浓度是否与 BC 相关，以及是否在健康马和小马之间存在差异。
动物
系统健康的客户拥有的小马（n = 101）和马（n = 51）。
方法
前瞻性观察研究。记录品种、体重、身高以及 BC 的主观和客观测量值，并测量 l-乳酸和葡萄糖浓度。建立 l-乳酸和葡萄糖浓度与 BC 之间的相关性。使用多变量模型研究 l-乳酸浓度、马种（小马或马）、BC、年龄和葡萄糖浓度之间的关系。
结果
检测到 l-乳酸浓度与平均 BC 评分（r = -0.29）、颈围：身高比（r = -0.27）和年龄（r = -0.27）呈弱但显著的负相关（P =.001）。葡萄糖浓度与颈长：颈围比（r = 0.37）和颈围：身高比（r = 0.31）呈显著正相关（P < .001）。l-乳酸和葡萄糖浓度呈弱相关（r = 0.15；P =.04）。在最终的多变量模型中，年龄（-0.02 ± 0.006；P =.001）和颈围：身高比（-1.74 ± 0.53；P =.001）与 l-乳酸浓度的自然对数（Lnl-Lactate）显著相关。这代表年龄每增加 1 岁，l-乳酸浓度降低 2%，颈围：身高比每增加 0.06 单位，l-乳酸浓度降低 10%。
结论和临床意义
在健康的马和小马中，年龄和 BC 显著影响 l-乳酸浓度。
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