Wei Binggan, Yu Jiangping, Wang Jing, Yang Linsheng, Li Hairong, Kong Chang, Xia Yajuan, Wu Kegong
Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, China.
Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, China; College of Resources and Environment, University of Chinese Academy of Sciences, China.
Environ Toxicol Pharmacol. 2017 Jul;53:89-94. doi: 10.1016/j.etap.2017.05.009. Epub 2017 May 12.
The associations between arsenic exposure, arsenic methylation, and the prevalence of skin lesions and hypertension are investigated. The results indicate that the HS (hypertension and skin lesions) group and the S (skin lesions) group have higher urinary concentrations of iAs (inorganic arsenic), MMA (monomethylarsonic acid), DMA (dimethylarsinous acid) and%MMA, and lower SMI (secondary arsenic methylation index) compared to the H (hypertension) and N (without both hypertension and skin lesions) groups. The arsenic content in water which caused H may be lower than that which caused HS and S. In addition, the odds ratios suggest that higher urinary concentrations of iAs and MMA, %iAs, %MMA and PMI elevate the prevalence of only hypertension and skin lesions, and both hypertension and skin lesions. However, higher%DMA and SMI, and lower%MMA increase the prevalence of both hypertension and skin lesions compared to that of only skin lesions. It can be concluded that skin lesions subjects have higher prevalence of hypertension. Hypertension subjects may have higher prevalence of skin lesions. Lower%DMA and SMI, higher%iAs, %MMA and PMI enhance the prevalence of only hypertension and skin lesions, and both hypertension and skin lesions. Moreover, iAs and MMA may have higher toxicity and lead to both hypertension and skin lesions than to only hypertension.
研究了砷暴露、砷甲基化与皮肤病变和高血压患病率之间的关联。结果表明，与高血压组（H组）和无高血压及皮肤病变组（N组）相比，高血压合并皮肤病变组（HS组）和皮肤病变组（S组）的尿中无机砷（iAs）、一甲基砷酸（MMA）、二甲基砷酸（DMA）浓度及MMA百分比更高，而二级砷甲基化指数（SMI）更低。导致高血压的水中砷含量可能低于导致高血压合并皮肤病变及仅导致皮肤病变的水中砷含量。此外，比值比表明，尿中iAs、MMA、iAs百分比、MMA百分比及初级甲基化指数（PMI）升高会增加仅患高血压、仅患皮肤病变以及同时患高血压和皮肤病变的患病率。然而，与仅患皮肤病变相比，更高的DMA百分比和SMI以及更低的MMA百分比会增加同时患高血压和皮肤病变的患病率。可以得出结论，皮肤病变患者高血压患病率更高。高血压患者皮肤病变患病率可能更高。更低的DMA百分比和SMI、更高的iAs百分比、MMA百分比及PMI会增加仅患高血压、仅患皮肤病变以及同时患高血压和皮肤病变的患病率。此外，iAs和MMA可能具有更高的毒性，导致同时患高血压和皮肤病变，而非仅导致高血压。
