Sammarco Rosa, Marra Maurizio, Di Guglielmo Maria Luisa, Naccarato Marianna, Contaldo Franco, Poggiogalle Eleonora, Donini Lorenzo Maria, Pasanisi Fabrizio
Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy.
Obes Facts. 2017;10(3):160-167. doi: 10.1159/000468153. Epub 2017 May 20.
The aim of this study was to evaluate the efficacy of a nutritional program, which is characterized by a different modulation of proteins, in adult patients with sarcopenic obesity.
We studied 18 obese women aged 41-74 years. Obesity was diagnosed as fat mass > 34.8% and sarcopenia was defined when lean body mass was <90% of the subject's ideal fat free mass. All subjects were randomly assigned to different nutritional interventions: Hypocaloric diet plus placebo (A) and hypocaloric high-protein diet (1.2-1.4 g / kg body weight reference / day) (B). Anthropometric measurements, body composition, resting energy expenditure, handgrip test, Short Physical Performance Battery (SPPB), and SF-36 questionnaire were evaluated at baseline and after 4 months.
Weight significantly decreased in both groups. Women with high-protein diet preserved lean body mass compared to low-calorie diet and improved significantly muscle strength; SPPB score did not change in both groups. SF-36 test showed a significant change for general health after 4 months in group B.
In our study, sarcopenic obese patients with high-protein diet showed an improvement in muscle strength. Furthermore, dietary protein enrichment may represent a protection from the risk of sarcopenia following a hypocaloric diet.
本研究旨在评估一项以蛋白质不同调节为特征的营养方案对患有肌肉减少性肥胖的成年患者的疗效。
我们研究了18名年龄在41 - 74岁之间的肥胖女性。肥胖被诊断为脂肪量>34.8%，当瘦体重<受试者理想无脂肪体重的90%时定义为肌肉减少症。所有受试者被随机分配到不同的营养干预组：低热量饮食加安慰剂（A组）和低热量高蛋白饮食（1.2 - 1.4克/千克体重参考量/天）（B组）。在基线和4个月后评估人体测量学指标、身体成分、静息能量消耗、握力测试、简短身体功能测试（SPPB）和SF - 36问卷。
两组体重均显著下降。与低热量饮食组相比，高蛋白饮食组的女性保留了瘦体重，肌肉力量显著改善；两组的SPPB评分均未改变。SF - 36测试显示B组在4个月后总体健康状况有显著变化。
在我们的研究中，高蛋白饮食的肌肉减少性肥胖患者肌肉力量有所改善。此外，饮食中蛋白质的富集可能对低热量饮食后肌肉减少症的风险起到保护作用。
