Kutlubay Zekayi, Tüzün Yalçın, Wolf Ronni
Department of Dermatology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey;
Department of Dermatology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey.
Skinmed. 2017 Apr 1;15(2):97-104. eCollection 2017.
The pathergy test produces a nonspecific hyperreactive lesion in Behçet's disease (BD), a finding that has been known since 1937. Pathergy refers to the development of new skin lesions or the aggravation of existing ones after trivial trauma. In clinical practice, the pathergy test induces a skin response by needleprick, with positive reactions manifesting as a papule or pustule developing by 48 hours. The pathergy test is one of the major features and diagnostic criteria of the disease. It is very similar to the erythematous papules or pustules that appear spontaneously in patients with BD. There is no standardized method for conducting the pathergy test. Intradermal, intravenous, and subcutaneous applications are used. There is no generally accepted opinion on which form of the test yields a higher positivity rate. The pathergy reaction is also reported in pyoderma gangrenosum, and has been noted in other neutrophilic dermatoses such as Sweet syndrome. The overall objective of this contribution is to provide a review of the available information, literature, and research relating to the pathergy test.
针刺反应试验可在白塞病（BD）中产生非特异性的高反应性病变，这一发现自1937年以来就已为人所知。针刺反应是指在轻微创伤后出现新的皮肤病变或现有病变加重。在临床实践中，针刺反应试验通过针刺诱发皮肤反应，阳性反应表现为在48小时内出现丘疹或脓疱。针刺反应试验是该疾病的主要特征和诊断标准之一。它与BD患者自发出现的红斑丘疹或脓疱非常相似。目前尚无进行针刺反应试验的标准化方法。采用皮内、静脉和皮下注射等方式。对于哪种试验形式的阳性率更高，尚无普遍接受的观点。坏疽性脓皮病中也有针刺反应的报道，在其他嗜中性皮肤病如Sweet综合征中也有发现。本论文的总体目标是对与针刺反应试验相关的现有信息、文献和研究进行综述。
