生物增强剂胡椒碱至少具有三种形态。
The Bioenhancer Piperine is at Least Trimorphic.
作者信息
Pfund Laura Y, Chamberlin Brianna L, Matzger Adam J
机构信息
Department of Chemistry and the Macromolecular Science and Engineering Program, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, United States.
出版信息
Cryst Growth Des. 2015 May 6;15(5):2047-2051. doi: 10.1021/acs.cgd.5b00278. Epub 2015 Mar 23.
Abstract
Polymer-induced heteronucleation (PIHn), a powerful crystalline polymorph discovery method, has revealed two novel polymorphs of the low solubility bioenhancer piperine. Both of these forms exhibit enhanced solubility when compared to the commercial polymorph, thereby potentially improving the efficacy of piperine as a bioenhancer. Structural comparison of the three forms reveals that π-π interactions are only present in the two newly discovered forms. Combined with the stability data this reveals that despite the extended conjugation present in the moleculesuch interactions are not preferred in thesolid state.
摘要
聚合物诱导异相成核（PIHn）是一种强大的晶体多晶型发现方法，它揭示了低溶解度生物增强剂胡椒碱的两种新型多晶型。与市售多晶型相比，这两种形式均表现出更高的溶解度，从而有可能提高胡椒碱作为生物增强剂的功效。三种形式的结构比较表明，π-π相互作用仅存在于两种新发现的形式中。结合稳定性数据表明，尽管分子中存在扩展共轭，但这种相互作用在固态中并非首选。
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