Department of Chemistry and the Macromolecular Science and Engineering Program, University of Michigan-Ann Arbor, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, USA.
J Am Chem Soc. 2012 Jun 20;134(24):9872-5. doi: 10.1021/ja302601f. Epub 2012 Jun 12.
The unprecedented polymorphism of the non-steroidal anti-inflammatory drug (NSAID) flufenamic acid (FFA) is described here. Nine polymorphs were accessed through the use of polymer-induced heteronucleation (PIHn) and solid-solid transformation at low temperature. Structural elucidation of six of these forms, in addition to the two previously known forms, makes FFA indisputably octamorphic. Although the structure of at least one other form of FFA remains elusive, the occurrence of most of these polymorphs under one crystallization condition through PIHn illustrates that a fine interplay exists among the kinetic factors that lead to phase selection in this NSAID.
本文描述了非甾体抗炎药（NSAID）氟芬那酸（FFA）前所未有的多晶型现象。通过使用聚合物诱导异核结晶（PIHn）和低温固-固转变，共获得了 9 种多晶型物。对其中 6 种形式的结构进行了阐明，此外还有之前已知的 2 种形式，这使得 FFA 无疑具有 8 种多晶型物。尽管至少还有一种 FFA 的多晶型物的结构仍然难以捉摸，但通过 PIHn 在一种结晶条件下出现了大多数这些多晶型物，这表明在这种 NSAID 中导致相选择的动力学因素之间存在着精细的相互作用。
