Ezawa Toshinari, Inoue Yutaka, Murata Isamu, Suzuki Mitsuaki, Takao Koichi, Sugita Yoshiaki, Kanamoto Ikuo
Faculty of Pharmacy and Pharmaceutical Science, Josai University, 1-1 Keyakidai, Sakado-shi, Saitama, 3500295, Japan.
Faculty of Science, Josai University, 1-1 Keyakidai, Sakado-shi, Saitama, 3500295, Japan.
Acta Crystallogr E Crystallogr Commun. 2020 Apr 9;76(Pt 5):646-650. doi: 10.1107/S2056989020004648. eCollection 2020 May 1.
The title compounds, 5-(2-1,3-benzodioxol-5-yl)--cyclo-hexyl-penta-2,4-dienamide, CHNO (I), and 5-(2-1,3-benzodioxol-5-yl)-1-(pyrrolidin-1-yl)penta-2,4-dien-1-one CHNO (II), are derivatives of piperine, which is known as a pungent component of pepper. Their geometrical parameters are similar to those of the three polymorphs of piperine, which indicate conjugation of electrons over the length of the mol-ecules. The extended structure of (I) features N-H⋯O amide hydrogen bonds, which generate (4) [010] chains. The crystal of (II) features aromatic π-π stacking, as for two of three known piperine polymorphs.
标题化合物5-(2-1,3-苯并二氧杂环戊烯-5-基)-环己基-戊-2,4-二烯酰胺（CHNO，I）和5-(2-1,3-苯并二氧杂环戊烯-5-基)-1-(吡咯烷-1-基)戊-2,4-二烯-1-酮（CHNO，II）是胡椒碱的衍生物，胡椒碱是胡椒中的一种辛辣成分。它们的几何参数与胡椒碱的三种多晶型物相似，这表明电子在分子长度上发生了共轭。（I）的扩展结构具有N-H⋯O酰胺氢键，形成了(4)[010]链。（II）的晶体具有芳香π-π堆积，与已知的三种胡椒碱多晶型物中的两种情况相同。
