Jin Jun, Choi Suh Hee, Lee Jung Eun, Joo Jin-Deok, Han Jung Ho, Park Su-Young, Kim Chae-Yong
Department of Neurosurgery, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do 13620, Republic of Korea.
Department of Neurosurgery, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Oncol Lett. 2017 May;13(5):3767-3773. doi: 10.3892/ol.2017.5918. Epub 2017 Mar 27.
Chemoradiotherapy with temozolomide is the current standard treatment option for patients with glioblastoma. However, the majority of patients with glioblastoma survive for <2 years. Therefore, it is necessary to develop more effective therapeutic strategies for the treatment of glioblastoma. 7-O-succinyl macrolactin A tromethamine salt (SMA salt), a macrolactin compound, is known to possess an antiangiogenic activity. The present study investigated the antitumor effects of SMA salt in the treatment of glioblastoma by evaluating and antitumor effects of SMA salt in an experimental glioblastoma model. The antitumor effects of the drug on human glioblastoma U87MG, U251MG and LN229 cell lines were assessed using cell viability, migration and invasion assays. Nude mice with established U87MG glioblastoma were assigned to either the control or SMA salt treatment group. The volume of tumors and the duration of survival were also measured. SMA salt affected cell viability and caused a concentration-dependent inhibition effect on the migration and invasion of glioblastoma cell lines. Animals in the SMA salt treatment group demonstrated a significant reduction in tumor volume and an increase in survival (P<0.05). Treatment with SMA salt presented more cytotoxic effects as well as anti-migration and anti-invasion activity compared with the control group and . These results suggest that SMA salt has significant antitumor effects on glioblastoma.
替莫唑胺同步放化疗是目前胶质母细胞瘤患者的标准治疗方案。然而，大多数胶质母细胞瘤患者的生存期不足2年。因此，有必要开发更有效的治疗策略来治疗胶质母细胞瘤。7 - O - 琥珀酰大乳香素A三甲胺盐（SMA盐）是一种大乳香素化合物，已知具有抗血管生成活性。本研究通过评估SMA盐在实验性胶质母细胞瘤模型中的抗肿瘤作用，来研究SMA盐治疗胶质母细胞瘤的效果。使用细胞活力、迁移和侵袭试验评估该药物对人胶质母细胞瘤U87MG、U251MG和LN229细胞系的抗肿瘤作用。将已建立U87MG胶质母细胞瘤的裸鼠分为对照组或SMA盐治疗组。还测量了肿瘤体积和生存期。SMA盐影响细胞活力，并对胶质母细胞瘤细胞系的迁移和侵袭产生浓度依赖性抑制作用。SMA盐治疗组的动物肿瘤体积显著减小，生存期延长（P<0.05）。与对照组相比，SMA盐治疗表现出更强的细胞毒性作用以及抗迁移和抗侵袭活性。这些结果表明，SMA盐对胶质母细胞瘤具有显著的抗肿瘤作用。
