Jin Jun, Hwang Kihwan, Joo Jin-Deok, Han Jung Ho, Kim Chae-Yong
Department of Neurosurgery, Seoul National University Bundang Hospital, Seongnam-Si, Korea.
Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.
Oncotarget. 2017 Dec 14;9(2):2140-2147. doi: 10.18632/oncotarget.23295. eCollection 2018 Jan 5.
7-O-succinyl macrolactin A has shown anti-inflammatory, anti-angiogenesis, and anti-metastatic effects. It also exhibits strong suppression of tumor growth. In our previous study, we assessed the anti-neoplastic effects of 7-O-succinyl macrolactin A tromethamine salt (SMA salt) on a glioma cell line. Moreover, according to our data, SMA salt might be contributed to the inhibitory effects on migration and invasion, as well as a cytotoxic effect on the glioblastoma cell lines. In the present study, we investigated the anti-tumor effects of combination therapy with SMA salt and temozolomide (TMZ) in glioblastoma cell lines. The combination therapy affected cell viability significantly, decreasing in glioblastoma cell lines. In cell migration assays, combination therapy showed more inhibitory effects than TMZ in these cell lines. The tumor volume was significantly decreased in the combination group compared with both TMZ and control groups by using the orthotopic mouse model. The effects of combination therapy with SMA salt and TMZ attributed to the inhibition of migration, invasion activities and anti-tumor effects. SMA salt could be one of the promising candidates for combination therapy in clinical settings.
7 - O - 琥珀酰大乳香素A已显示出抗炎、抗血管生成和抗转移作用。它还对肿瘤生长有强烈抑制作用。在我们之前的研究中，我们评估了7 - O - 琥珀酰大乳香素A三羟甲基氨基甲烷盐（SMA盐）对胶质瘤细胞系的抗肿瘤作用。此外，根据我们的数据，SMA盐可能对迁移和侵袭具有抑制作用，并对胶质母细胞瘤细胞系具有细胞毒性作用。在本研究中，我们研究了SMA盐与替莫唑胺（TMZ）联合治疗对胶质母细胞瘤细胞系的抗肿瘤作用。联合治疗显著影响细胞活力，使胶质母细胞瘤细胞系中的细胞活力降低。在细胞迁移试验中，联合治疗在这些细胞系中显示出比TMZ更强的抑制作用。通过原位小鼠模型，联合治疗组的肿瘤体积与TMZ组和对照组相比均显著减小。SMA盐与TMZ联合治疗的效果归因于对迁移、侵袭活性的抑制和抗肿瘤作用。SMA盐可能是临床联合治疗中有前景的候选药物之一。
