基于钆塞酸二钠的磁共振成像用于预测肝脏对门静脉栓塞的反应
Gd-EOB-DTPA based magnetic resonance imaging for predicting liver response to portal vein embolization.
作者信息
Szklaruk Janio, Luersen Gustavo, Ma Jingfei, Wei Wei, Underwood Michelle
机构信息
Janio Szklaruk, Jingfei Ma, Wei Wei, Michelle Underwood, Department of Diagnostic Radiology, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States.
出版信息
World J Radiol. 2017 Apr 28;9(4):199-205. doi: 10.4329/wjr.v9.i4.199.
AIM
To evaluate the correlation between degree of kinetic growth (kGR) of the liver following portal vein embolization (PVE) liver and the enhancement of the during the hepatobiliary phase of contrast administration and to evaluate if the enhancement can be used to predict response to PVE prior to the procedure.
METHODS
Seventeen patients were consented for the prospective study. All patients had an MR of the abdomen with Gd-EOB-DTPA. Fourteen patients underwent PVE. The correlation between the kGR of the liver and the degree of enhancement was evaluated with linear regression (strong assumptions) and Spearman's correlation test (rank based, no assumptions). The correlation was examined for the whole liver, segments I, VIII, VII, VI, V, IV, right liver and left liver.
RESULTS
There was no correlation between the degree of enhancement during the hepatobiliary phase and kGR for any segment, lobe of the liver or whole liver (P = 0.19 to 0.91 by Spearman's correlation test).
CONCLUSION
The relative enhancement of the liver during the hepatobiliary phase with Gd-EOB-DTPA cannot be used to predict the liver response to PVE.
目的
评估门静脉栓塞术（PVE）后肝脏的动态生长程度（kGR）与对比剂注射后肝胆期肝脏强化之间的相关性，并评估该强化是否可用于在手术前预测PVE的反应。
方法
17例患者同意参加前瞻性研究。所有患者均接受了使用钆塞酸二钠（Gd-EOB-DTPA）的腹部磁共振成像检查。14例患者接受了PVE。采用线性回归（强假设）和Spearman相关性检验（基于秩次，无假设）评估肝脏kGR与强化程度之间的相关性。对整个肝脏、Ⅰ段、Ⅷ段、Ⅶ段、Ⅵ段、Ⅴ段、Ⅳ段、右肝和左肝进行相关性检查。
结果
通过Spearman相关性检验，对于肝脏的任何节段、叶或整个肝脏，肝胆期强化程度与kGR之间均无相关性（P = 0.19至0.91）。
结论
使用钆塞酸二钠（Gd-EOB-DTPA）时，肝脏在肝胆期的相对强化不能用于预测肝脏对PVE的反应。
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