Twomey Maria, Fleming Hannah, Moloney Fiachra, Murphy Kevin P, Crush Lee, O'Neill Siobhan B, Flanagan Oisin, James Karl, Bogue Conor, O'Connor Owen J, Maher Michael M
Maria Twomey, Hannah Fleming, Fiachra Moloney, Kevin P Murphy, Lee Crush, Siobhan B O'Neill, Oisin Flanagan, Karl James, Conor Bogue, Owen J O'Connor, Michael M Maher, Department of Radiology, Cork University Hospital, Wilton, T12 DC4A Cork, Ireland.
World J Radiol. 2017 Apr 28;9(4):206-211. doi: 10.4329/wjr.v9.i4.206.
To evaluate the association between C-reactive protein (CRP) and radiological evidence of lower respiratory tract infection (LRTI) in infants.
All patients aged less than 4 years who presented with suspected lower respiratory tract infection, who received a peri-presentation chest radiograph and CRP blood measurement over an 18-mo period were included in the study. Age, gender, source of referral, CRP, white cell count, neutrophil count along with the patients' symptoms and radiologist's report were recorded.
Three hundred and eleven patients met the inclusion criteria. Abnormal chest radiographs were more common in patients with elevated CRP levels ( < 0.01). Radiologic signs of LRTI were identified in 73.7% of chest radiographs when a patient had a CRP level between 50-99 mg/L. CRP levels were a better predictor of positive chest radiograph findings for those aged greater than I year compared to those 1 year or less.
CRP may be used in patients with suspected LRTI diagnosis to select those who are likely to have positive findings on chest radiograph, thus reducing unnecessary chest radiographs.
评估婴儿C反应蛋白（CRP）与下呼吸道感染（LRTI）影像学证据之间的关联。
本研究纳入了所有年龄小于4岁、疑似下呼吸道感染、在18个月期间接受了就诊时胸部X线片和CRP血液检测的患者。记录年龄、性别、转诊来源、CRP、白细胞计数、中性粒细胞计数以及患者症状和放射科医生的报告。
311例患者符合纳入标准。CRP水平升高的患者中，胸部X线片异常更为常见（<0.01）。当患者CRP水平在50-99mg/L之间时，73.7%的胸部X线片发现了LRTI的影像学征象。与1岁及以下儿童相比，CRP水平对1岁以上儿童胸部X线片阳性结果的预测性更好。
CRP可用于疑似LRTI诊断的患者，以筛选出胸部X线片可能有阳性结果的患者，从而减少不必要的胸部X线检查。
