Alshaya Dalal S
Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Saudi J Biol Sci. 2022 Aug;29(8):103311. doi: 10.1016/j.sjbs.2022.103311. Epub 2022 May 20.
Depression is a complex psychiatric disturbance involving many environmental, genetic, and epigenetic factors. Until now, genetic, and non-genetic studies are still on the way to understanding the complex mechanism of this disease, and there are still many questions that have not yet been answered. Depression includes a large spectrum of heterogeneous symptoms correlated to the deficit of a range of psychological, cognitive, and emotional processes, and it affects various age groups. It is classified into several types according to the severity of symptoms, time of occurrence, and time. Following the World Health Organization (WHO), depression attacks near 350 million persons globally. Several factors overlap in causing depression, including genetic and epigenetic factors, environmental conditions, various stresses, lack of some nutrients to which people are exposed, and excessive stress and abuse in childhood. This study included conducting surveys on depression and new treatment trends based on epigenetic factors associated with the occurrence of the disease. Epigenetic factors provide a completely novel dimension to therapeutic approaches as most diseases are not monogenic, and it is likely that the environment has a significant contribution. Epigenetic inheritance is included in many mental and psychiatric disorders such as depression. In general, epigenetic modifications could be summarized in 3 major points: DNA methylation, histone modification, and non-mediated regulation of RNA (ncRNA). This study also describes some genes associated with one of the depressive disorders using bioinformatics tools and gene bank and had the genes: and . As in this study, the awareness of Saudi society about depression and its genetic and non-genetic causes was estimated. The results showed that an encouraging percentage of more than half of the research sample possessed correct information about this disorder.
抑郁症是一种复杂的精神障碍，涉及许多环境、遗传和表观遗传因素。到目前为止，遗传和非遗传研究仍在探索这种疾病的复杂机制，仍有许多问题尚未得到解答。抑郁症包括一系列与多种心理、认知和情感过程缺陷相关的异质性症状，并且影响各个年龄组。根据症状严重程度、发病时间和时长，它被分为几种类型。根据世界卫生组织（WHO）的数据，全球近3.5亿人受到抑郁症的侵袭。导致抑郁症的因素有多个重叠，包括遗传和表观遗传因素、环境条件、各种压力、人们接触到的某些营养素缺乏，以及童年时期的过度压力和虐待。本研究包括基于与该疾病发生相关的表观遗传因素对抑郁症和新治疗趋势进行调查。表观遗传因素为治疗方法提供了一个全新的维度，因为大多数疾病并非单基因疾病，环境很可能起到了重要作用。表观遗传遗传存在于许多精神和心理障碍中，如抑郁症。一般来说，表观遗传修饰可概括为三个主要方面：DNA甲基化、组蛋白修饰和RNA的非介导调控（ncRNA）。本研究还使用生物信息学工具和基因库描述了一些与其中一种抑郁症相关的基因，这些基因有： 和 。正如本研究中所做的那样，对沙特社会对抑郁症及其遗传和非遗传病因的认知情况进行了评估。结果显示，超过一半的研究样本中令人鼓舞的比例对这种疾病拥有正确的信息。
