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Am J Case Rep. 2021 Jul 1;22:e931819. doi: 10.12659/AJCR.931819.

本文引用的文献

1
CA 19-9 in the presence of obstructive jaundice due to Mirizzi syndrome.因Mirizzi综合征导致梗阻性黄疸时的CA 19-9
Isr Med Assoc J. 2015 Jan;17(1):60-1.
2
Acute acalculous cholecystitis determining Mirizzi syndrome: case report and literature review.急性非结石性胆囊炎并发Mirizzi综合征：病例报告及文献复习
BMC Surg. 2014 Nov 15;14:90. doi: 10.1186/1471-2482-14-90.
3
Carbohydrate 19.9 antigen serum levels in liver disease.肝病患者血清 19.9 号碳水化合物抗原水平。
Biomed Res Int. 2013;2013:531640. doi: 10.1155/2013/531640. Epub 2013 Oct 27.
4
CA19-9 serum levels in obstructive jaundice: clinical value in benign and malignant conditions.阻塞性黄疸患者的CA19-9血清水平：在良性和恶性疾病中的临床价值
Am J Surg. 2009 Sep;198(3):333-9. doi: 10.1016/j.amjsurg.2008.12.031. Epub 2009 Apr 17.
5
An exceptional high concentration of serum CA 19.9 in a patient with alcoholic liver disease.一名酒精性肝病患者血清CA 19.9浓度异常升高。
Gut. 1997 Oct;41(4):577.
6
Persistent elevation of serum CA 19-9 with no evidence of malignant disease.血清CA 19-9持续升高，无恶性疾病证据。
Dig Liver Dis. 2009 May;41(5):357-63. doi: 10.1016/j.dld.2008.04.002. Epub 2008 Jul 3.
7
The combined elevation of tumor markers CA 19-9 and CA 125 in liver disease patients is highly specific for severe liver fibrosis.
Dig Dis Sci. 2006 Feb;51(2):338-45. doi: 10.1007/s10620-006-3135-x.
8
[CA19-9 has no value as a tumor marker in obstructive jaundice].[CA19-9作为肿瘤标志物在梗阻性黄疸中无价值]
Schweiz Med Wochenschr. 1999 Jan 23;129(3):77-9.
9
The effect of benign and malignant liver disease on the tumour markers CA19-9 and CEA.良性和恶性肝脏疾病对肿瘤标志物CA19-9和癌胚抗原（CEA）的影响。
Ann Clin Biochem. 1998 Jan;35 ( Pt 1):99-103. doi: 10.1177/000456329803500113.
10
Marked increase in serum CA 19-9 level in patients with alcoholic cirrhosis: report of four cases.
Eur J Gastroenterol Hepatol. 1996 Nov;8(11):1129-31. doi: 10.1097/00042737-199611000-00019.

Mirrizi综合征与无恶性疾病情况下显著升高的糖类抗原19-9水平

Mirrizi Syndrome and Markedly Elevated Levels of Carbohydrate Antigen 19-9 in the Absence of Malignant Disease.

作者信息

Shah Natasha, Tetangco Eula, Arshad Hafiz Muhammad Sharjeel, Raddawi Hareth

机构信息

University of Illinois at Chicago/Christ Hospital Advocate Medical Center, Oak Lawn, IL, USA.

出版信息

Case Rep Gastrointest Med. 2017;2017:2416901. doi: 10.1155/2017/2416901. Epub 2017 Apr 26.

DOI:10.1155/2017/2416901
PMID:28529808
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5424187/
Abstract

Elevated carbohydrate antigen 19-9 (CA19-9) beyond 1000 U/L occurs in nonneoplastic conditions which is causing questioning of the use of CA19-9 as a marker for screening. We report a case where a 51-year-old male with Mirrizi Syndrome (MS) presented with markedly increased CA19-9 level (4,618 U/mL). MS is a rare complication characterized by compression of the common bile or hepatic duct caused by an impacted gallstone in the cystic duct or neck of the gallbladder. Biliary epithelial cells secrete CA19-9: it is hypothesized that increased proliferation of such cells caused by inflammation leads to increased secretion. CA19-9 should not be used as a diagnostic tool, but rather for surveillance.

摘要

糖类抗原19-9（CA19-9）水平超过1000 U/L也会出现在非肿瘤性疾病中，这引发了对将CA19-9用作筛查标志物的质疑。我们报告了一例51岁患有Mirrizi综合征（MS）的男性患者，其CA19-9水平显著升高（4618 U/mL）。MS是一种罕见的并发症，其特征是胆囊管或胆囊颈部的结石嵌顿导致胆总管或肝管受压。胆管上皮细胞分泌CA19-9：据推测，炎症引起的此类细胞增殖增加会导致分泌增加。CA19-9不应用作诊断工具，而应用于监测。