Oinuma Shinichiro, Yoshio Deguchi, Omotaka Syunsuke, Terunuma Takuya, Kasagi Shinya, Kimura Hironobu, Yokoyama Noboru, Inoue Haruhiro
Digestive Disease Center, Showa University Koto Toyosu Hospital, 5-1-38 Toyosu, Koto-Ku, Tokyo, 135-8577, Japan.
Surg Case Rep. 2023 May 3;9(1):69. doi: 10.1186/s40792-023-01648-1.
CA19-9 is strongly expressed in malignant tumors of the digestive system and is widely used as a marker for gastrointestinal cancer. In this report, we describe a case of acute cholecystitis in which CA19-9 was markedly elevated.
A 53-year-old man was admitted to our hospital with a diagnosis of acute cholecystitis after being referred to our hospital with a chief complaint of fever and right hypochondrial pain. CA19-9 was abnormally high at 17,539.1 U/ml. Although the possibility of malignancy was considered, there was no obvious malignant lesion on imaging; the patient was diagnosed with cholecystitis, and laparoscopic cholecystectomy was performed the day after admission. The surgical specimen showed no malignant findings either grossly or in the final pathological examination. There were no complications in the patient's postoperative course, and he was discharged from the hospital on the third postoperative day. CA19-9 level quickly returned to within normal range after surgery.
In acute cholecystitis, CA19-9 levels exceeding 10,000 U/ml are very rare. We report a case of acute cholecystitis without malignant findings despite a high CA19-9 level.
CA19-9在消化系统恶性肿瘤中高表达，被广泛用作胃肠道癌的标志物。在本报告中，我们描述了一例CA19-9显著升高的急性胆囊炎病例。
一名53岁男性因发热和右季肋部疼痛为主诉被转诊至我院，诊断为急性胆囊炎后入院。CA19-9异常升高至17539.1 U/ml。尽管考虑了恶性肿瘤的可能性，但影像学检查未发现明显恶性病变；患者被诊断为胆囊炎，并于入院次日行腹腔镜胆囊切除术。手术标本在大体及最终病理检查中均未发现恶性表现。患者术后过程无并发症，术后第三天出院。术后CA19-9水平迅速恢复至正常范围。
在急性胆囊炎中，CA19-9水平超过10000 U/ml非常罕见。我们报告了一例尽管CA19-9水平高但无恶性表现的急性胆囊炎病例。
