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Clinical safety and activity of pembrolizumab in patients with malignant pleural mesothelioma (KEYNOTE-028): preliminary results from a non-randomised, open-label, phase 1b trial.帕博利珠单抗治疗恶性胸膜间皮瘤患者的临床安全性和疗效（KEYNOTE-028）：一项非随机、开放标签、Ib 期试验的初步结果。
Lancet Oncol. 2017 May;18(5):623-630. doi: 10.1016/S1470-2045(17)30169-9. Epub 2017 Mar 11.
2
The Impact of Postoperative Radiotherapy for Thymoma and Thymic Carcinoma.胸腺瘤和胸腺癌术后放疗的影响。
J Thorac Oncol. 2017 Apr;12(4):734-744. doi: 10.1016/j.jtho.2017.01.002. Epub 2017 Jan 25.
3
Impact of Intensity-Modulated Radiation Therapy Technique for Locally Advanced Non-Small-Cell Lung Cancer: A Secondary Analysis of the NRG Oncology RTOG 0617 Randomized Clinical Trial.调强放射治疗技术对局部晚期非小细胞肺癌的影响：NRG肿瘤学RTOG 0617随机临床试验的二次分析
J Clin Oncol. 2017 Jan;35(1):56-62. doi: 10.1200/JCO.2016.69.1378. Epub 2016 Oct 31.
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National Cancer Database Analysis of Proton Versus Photon Radiation Therapy in Non-Small Cell Lung Cancer.非小细胞肺癌中质子放疗与光子放疗的国家癌症数据库分析
Int J Radiat Oncol Biol Phys. 2017 Jan 1;97(1):128-137. doi: 10.1016/j.ijrobp.2016.10.001. Epub 2016 Oct 11.
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Modern radiotherapy using image guidance for unresectable non-small cell lung cancer can improve outcomes in patients treated with chemoradiation therapy.采用图像引导的现代放射疗法用于不可切除的非小细胞肺癌，可改善接受放化疗患者的治疗效果。
J Thorac Dis. 2016 Sep;8(9):2602-2609. doi: 10.21037/jtd.2016.08.95.
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Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer.帕博利珠单抗对比化疗用于 PD-L1 阳性非小细胞肺癌。
N Engl J Med. 2016 Nov 10;375(19):1823-1833. doi: 10.1056/NEJMoa1606774. Epub 2016 Oct 8.
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Phase III Randomized Trial of Ipilimumab Plus Etoposide and Platinum Versus Placebo Plus Etoposide and Platinum in Extensive-Stage Small-Cell Lung Cancer.三期随机临床试验：伊匹单抗联合依托泊苷和铂类药物与安慰剂联合依托泊苷和铂类药物治疗广泛期小细胞肺癌。
J Clin Oncol. 2016 Nov 1;34(31):3740-3748. doi: 10.1200/JCO.2016.67.6601.
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First Clinical Investigation of Cone Beam Computed Tomography and Deformable Registration for Adaptive Proton Therapy for Lung Cancer.首次临床研究：锥形束计算机断层扫描和形变配准在肺癌自适应质子治疗中的应用。
Int J Radiat Oncol Biol Phys. 2016 May 1;95(1):549-559. doi: 10.1016/j.ijrobp.2016.01.055. Epub 2016 Feb 4.
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Consensus Statement on Proton Therapy in Early-Stage and Locally Advanced Non-Small Cell Lung Cancer.早期和局部晚期非小细胞肺癌质子治疗共识声明
Int J Radiat Oncol Biol Phys. 2016 May 1;95(1):505-516. doi: 10.1016/j.ijrobp.2016.01.036. Epub 2016 Jan 23.
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Risk factors and management of oligometastatic non-small cell lung cancer.寡转移非小细胞肺癌的危险因素与管理
Ther Adv Respir Dis. 2016 Aug;10(4):338-48. doi: 10.1177/1753465816642636. Epub 2016 Apr 8.

Harnessing the potential synergy of combining radiation therapy and immunotherapy for thoracic malignancies.

作者信息

Simone Charles B, Berman Abigail T, Jabbour Salma K

机构信息

Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USA. (Email:

Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. (Email:

出版信息

Transl Lung Cancer Res. 2017 Apr;6(2):109-112. doi: 10.21037/tlcr.2017.04.05.

DOI:10.21037/tlcr.2017.04.05
PMID:28529893
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5420536/
Abstract
摘要