Francik Renata, Kryczyk-Kozioł Jadwiga, Francik Sławomir, Gryboś Ryszard, Krośniak Mirosław
Department of Bioorganic Chemistry, Chair of Organic Chemistry, Jagiellonian University Medical College, Krakow, Poland.
Department of Food Chemistry and Nutrition, Jagiellonian University Medical College, Krakow, Poland.
Biomed Res Int. 2017;2017:6950516. doi: 10.1155/2017/6950516. Epub 2017 Apr 26.
Vanadium is a trace element mainly connected with regulation of insulin metabolism which is particularly important in diabetes. In recent years, organic complexes of vanadium seem to be more interesting than inorganic salts. Nevertheless, the effect of vanadium on lipid metabolism is still a problematic issue; therefore, the main purpose of this study was to investigate the effect of 3 organic complexes of vanadium such as sodium (2,2'-bipyridine)oxidobisperoxovanadate(V) octahydrate, bis(2,2'-bipyridine)oxidovanadium(IV) sulfate dehydrate, and bis(4,4'-dimethyl-2,2'-bipyridine)oxidovanadium(IV) sulfate dihydrate in conjunction with high-fat as well as control diet in nondiabetes model on the following lipid parameters: total cholesterol, triglycerides, and high density lipoprotein as well as activity of paraoxonase 1. All of these parameters were determined in plasma of Wistar rats. The most significant effect was observed in case of bis(4,4'-dimethyl-2,2' bipyridine)oxidovanadium(IV) sulfate dehydrate in rats fed with high-fat diet. Based on our research, bis(4,4'-dimethyl-2,2'-bipyridine)oxidovanadium(IV) sulfate dihydrate should be the aim of further research and perhaps it will be an important factor in the regulation of lipid metabolism.
钒是一种微量元素，主要与胰岛素代谢的调节有关，这在糖尿病中尤为重要。近年来，钒的有机配合物似乎比无机盐更具吸引力。然而，钒对脂质代谢的影响仍然是一个有争议的问题；因此，本研究的主要目的是研究三种钒有机配合物，如八水合（2,2'-联吡啶）氧化双过氧钒（V）酸钠、硫酸二水合双（2,2'-联吡啶）氧化钒（IV）和二水合双（4,4'-二甲基-2,2'-联吡啶）氧化钒（IV）硫酸盐，在非糖尿病模型中与高脂饮食以及对照饮食联合使用时，对以下脂质参数的影响：总胆固醇、甘油三酯、高密度脂蛋白以及对氧磷酶1的活性。所有这些参数均在Wistar大鼠的血浆中测定。在喂食高脂饮食的大鼠中，观察到二水合双（4,4'-二甲基-2,2'-联吡啶）氧化钒（IV）硫酸盐的效果最为显著。基于我们的研究，二水合双（4,4'-二甲基-2,2'-联吡啶）氧化钒（IV）硫酸盐应成为进一步研究的目标，也许它将是调节脂质代谢的一个重要因素。
