Department of Occupational Health, West China School of Public Health, Sichuan University, No, 16, Section 3, South Renmin Road, Chengdu, Sichuan 610041, China.
Lipids Health Dis. 2014 Feb 24;13:39. doi: 10.1186/1476-511X-13-39.
Some experimental animal studies reported that vanadium had beneficial effects on blood total cholesterol (TC) and triglyceride (TG). However, the relationship between vanadium exposure and lipid, lipoprotein profiles in human subjects remains uncertain. This study aimed to compare the serum lipid and lipoprotein profiles of occupational vanadium exposed and non-exposed workers, and to provide human evidence on serum lipid, lipoprotein profiles and atherogenic indexes changes in relation to vanadium exposure.
This cross-sectional study recruited 533 vanadium exposed workers and 241 non-exposed workers from a Steel and Iron Group in Sichuan, China. Demographic characteristics and occupational information were collected through questionnaires. Serum lipid and lipoprotein levels were measured for all participants. The ratios of total cholesterol to high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) to HDL-C and apoB to apoA-I were used as atherogenic indexes. A general linear model was applied to compare outcomes of the two groups while controlling possible confounders and multivariate logistic regression was performed to evaluate the relationship between low HDL-C level, abnormal atherogenic index and vanadium exposure.
Higher levels of HDL-C and apoA-I could be observed in the vanadium exposed group compared with the control group (P < 0.05). Furthermore, atherogenic indexes (TC/HDL-C, LDL-C/HDL-C, and apoB/apoA-I ratios) were found statistically lower in the vanadium exposed workers (P < 0.05). Changes in HDL-C, TC/HDL-C, and LDL-C/HDL-C were more pronounced in male workers than that in female workers. In male workers, after adjusting for potential confounding variables as age, habits of smoking and drinking, occupational vanadium exposure was still associated with lower HDL-C (OR 0.41; 95% CI, 0.27-0.62) and abnormal atherogenic index (OR 0.38; 95% CI, 0.20-0.70).
Occupational vanadium exposure appears to be associated with increased HDL-C and apoA-I levels and decreased atherogenic indexes. Among male workers, a significantly negative association existed between low HDL-C level, abnormal atherogenic index and occupational vanadium exposure. This suggests vanadium has beneficial effects on blood levels of HDL-C and apoA-I.
一些实验动物研究报告称，钒对血液总胆固醇（TC）和甘油三酯（TG）有有益影响。然而，在人类受试者中，钒暴露与血脂、脂蛋白谱之间的关系仍不确定。本研究旨在比较职业性钒暴露工人和非暴露工人的血清脂质和脂蛋白谱，并提供与钒暴露相关的血清脂质、脂蛋白谱和致动脉粥样硬化指数变化的人体证据。
这项横断面研究招募了来自中国四川某钢铁集团的 533 名钒暴露工人和 241 名非暴露工人。通过问卷收集人口统计学特征和职业信息。所有参与者均测量血清脂质和脂蛋白水平。总胆固醇与高密度脂蛋白胆固醇（HDL-C）之比、低密度脂蛋白胆固醇（LDL-C）与 HDL-C 之比和载脂蛋白 B 与载脂蛋白 A-I 之比用作致动脉粥样硬化指数。应用一般线性模型比较两组结果，同时控制可能的混杂因素，并进行多变量逻辑回归评估低 HDL-C 水平、异常致动脉粥样硬化指数与钒暴露之间的关系。
与对照组相比，钒暴露组的 HDL-C 和载脂蛋白 A-I 水平更高（P<0.05）。此外，钒暴露工人的致动脉粥样硬化指数（TC/HDL-C、LDL-C/HDL-C 和载脂蛋白 B/载脂蛋白 A-I 比值）较低（P<0.05）。在男性工人中，HDL-C、TC/HDL-C 和 LDL-C/HDL-C 的变化比女性工人更为明显。在男性工人中，在校正年龄、吸烟和饮酒习惯等潜在混杂因素后，职业性钒暴露仍与低 HDL-C（比值比 0.41；95%置信区间 0.27-0.62）和异常致动脉粥样硬化指数（比值比 0.38；95%置信区间 0.20-0.70）相关。
职业性钒暴露似乎与 HDL-C 和载脂蛋白 A-I 水平升高以及致动脉粥样硬化指数降低有关。在男性工人中，低 HDL-C 水平、异常致动脉粥样硬化指数与职业性钒暴露之间存在显著的负相关关系。这表明钒对血液 HDL-C 和载脂蛋白 A-I 水平有有益的影响。
