浓缩红细胞单位白细胞去除术在创伤患者中的作用：综述
Role of Leukoreduction of Packed Red Blood Cell Units in Trauma Patients: A Review.
作者信息
Kim Young, Xia Brent T, Chang Alex L, Pritts Timothy A
机构信息
Department of Surgery and Institute for Military Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0558, the United States.
出版信息
Int J Hematol Res. 2016 Jun;2(2):124-129. doi: 10.17554/j.issn.2409-3548.2016.02.31. Epub 2016 Jun 27.
Abstract
Hemorrhagic shock is a leading cause of mortality within the trauma population, and blood transfusion is the standard of care. Leukoreduction filters remove donor leukocytes prior to transfusion of blood products. While the benefits of leukocyte depletion are well documented in scientific literature, these benefits do not translate directly to the clinical setting. This review summarizes current research regarding leukoreduction in the clinical arena, as well as studies performed exclusively in the trauma population.
摘要
失血性休克是创伤人群死亡的主要原因，输血是标准治疗方法。白细胞滤除器在输血前可去除供体白细胞。虽然白细胞去除的益处已在科学文献中得到充分证明，但这些益处并未直接转化为临床应用。本综述总结了目前关于临床领域白细胞滤除的研究，以及专门针对创伤人群进行的研究。
相似文献
1
Role of Leukoreduction of Packed Red Blood Cell Units in Trauma Patients: A Review.浓缩红细胞单位白细胞去除术在创伤患者中的作用：综述
Int J Hematol Res. 2016 Jun;2(2):124-129. doi: 10.17554/j.issn.2409-3548.2016.02.31. Epub 2016 Jun 27.
2
The use of leukoreduced red blood cell products is associated with fewer infectious complications in trauma patients.使用白细胞滤除的红细胞制品与创伤患者较少的感染并发症相关。
Am J Surg. 2008 Jul;196(1):56-61. doi: 10.1016/j.amjsurg.2007.08.063. Epub 2008 May 29.
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Clinical outcomes following institution of the Canadian universal leukoreduction program for red blood cell transfusions.加拿大红细胞输血普遍白细胞去除计划实施后的临床结果。
JAMA. 2003 Apr 16;289(15):1941-9. doi: 10.1001/jama.289.15.1941.
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Effects of Leukoreduction and Storage on Erythrocyte Phosphatidylserine Expression and Eicosanoid Concentrations in Units of Canine Packed Red Blood Cells.白细胞滤除和储存对犬浓缩红细胞单位中红细胞磷脂酰丝氨酸表达和类花生酸浓度的影响。
J Vet Intern Med. 2017 Mar;31(2):410-418. doi: 10.1111/jvim.14664. Epub 2017 Jan 31.
5
Leukoreduction before red blood cell transfusion has no impact on mortality in trauma patients.红细胞输血前进行白细胞过滤对创伤患者的死亡率没有影响。
J Surg Res. 2007 Mar;138(1):32-6. doi: 10.1016/j.jss.2006.07.048. Epub 2006 Dec 11.
6
Evaluation of a new prestorage leukoreduction filter for red blood cell units.新型红细胞单位储存前白细胞滤除器的评估
Vox Sang. 1997;72(2):101-6. doi: 10.1046/j.1423-0410.1997.7220101.x.
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Clinical outcomes following institution of universal leukoreduction of blood transfusions for premature infants.对早产儿实施普遍白细胞滤除输血后的临床结果。
JAMA. 2003 Apr 16;289(15):1950-6. doi: 10.1001/jama.289.15.1950.
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Use of a prestorage leukoreduction filter effectively removes leukocytes from canine whole blood while preserving red blood cell viability.使用预储存白细胞滤除器可有效从犬全血中去除白细胞，同时保持红细胞活力。
J Vet Intern Med. 2000 Jul-Aug;14(4):412-7. doi: 10.1892/0891-6640(2000)014<0412:uoaplf>2.3.co;2.
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Depletion of resident Chlamydia pneumoniae through leukoreduction by filtration of blood for transfusion.通过对用于输血的血液进行过滤白细胞去除术来减少宿主体内的肺炎衣原体。
J Clin Microbiol. 2005 Sep;43(9):4580-4. doi: 10.1128/JCM.43.9.4580-4584.2005.
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Randomized trial comparing packed red cell blood transfusion with and without leukocyte depletion for gastrointestinal surgery.比较有和没有白细胞去除的浓缩红细胞输血用于胃肠手术的随机试验。
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Evaluation of leukocyte depletion of packed red blood cells for the prevention of clinically observed transfusion reactions at a medical center in Eastern Taiwan.台湾东部某医学中心对浓缩红细胞白细胞去除术预防临床观察到的输血反应的评估。
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Effects of whole blood leukoreduction on platelet function and hemostatic parameters.全血白细胞去除术对血小板功能和止血参数的影响。
Transfus Med. 2019 Oct;29(5):351-357. doi: 10.1111/tme.12622. Epub 2019 Aug 5.
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Effects of platelet-sparing leukocyte reduction and agitation methods on in vitro measures of hemostatic function in cold-stored whole blood.血小板保存白细胞减少和搅拌方法对冷藏全血体外止血功能的影响。
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本文引用的文献
1
Molecular mechanisms of erythrocyte aging.红细胞衰老的分子机制。
Biol Chem. 2015 Jun;396(6-7):621-31. doi: 10.1515/hsz-2014-0292.
2
Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial.严重创伤患者血浆、血小板和红细胞以1:1:1与1:1:2比例输注及死亡率：PROPPR随机临床试验
JAMA. 2015 Feb 3;313(5):471-82. doi: 10.1001/jama.2015.12.
3
Do leukoreduction filters passively reduce the transmission risk of human granulocytic anaplasmosis?白细胞滤除器能否被动降低人粒细胞无形体病的传播风险？
Transfusion. 2015 Jun;55(6):1242-8. doi: 10.1111/trf.12976. Epub 2014 Dec 30.
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Adverse effects of transfusion.输血的不良反应。
Cancer Control. 2015 Jan;22(1):16-25. doi: 10.1177/107327481502200104.
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Increasing trauma deaths in the United States.美国创伤死亡人数增加。
Ann Surg. 2014 Jul;260(1):13-21. doi: 10.1097/SLA.0000000000000600.
6
An innovative biologic recycling process of leukoreduction filters to produce active human antimicrobial peptides.一种创新的白细胞去除过滤器的生物再循环工艺，用于生产活性的人类抗菌肽。
Transfusion. 2014 May;54(5):1332-9. doi: 10.1111/trf.12444. Epub 2013 Oct 10.
7
Leukoreduction and ultraviolet treatment reduce both the magnitude and the duration of the HLA antibody response.白细胞去除和紫外线处理均可降低 HLA 抗体反应的幅度和持续时间。
Transfusion. 2014 Mar;54(3):672-80. doi: 10.1111/trf.12317. Epub 2013 Jun 30.
8
The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks.前瞻性、观察性、多中心、严重创伤输血（PROMMTT）研究：具有竞争风险的时变治疗的比较效果。
JAMA Surg. 2013 Feb;148(2):127-36. doi: 10.1001/2013.jamasurg.387.
9
Massive Bleeding and Massive Transfusion.大出血与大量输血
Transfus Med Hemother. 2012 Apr;39(2):73-84. doi: 10.1159/000337250. Epub 2012 Mar 12.
10
Microparticles from stored red blood cells activate neutrophils and cause lung injury after hemorrhage and resuscitation.储存的红细胞释放的微粒激活中性粒细胞，并在出血和复苏后导致肺部损伤。
J Am Coll Surg. 2012 Apr;214(4):648-55; discussion 656-7. doi: 10.1016/j.jamcollsurg.2011.12.032. Epub 2012 Feb 17.
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