de Vos Willem M
Laboratory of Microbiology, Wageningen University, The Netherlands.
Immunobiology Research Program, University of Helsinki, Finland.
Microbiology (Reading). 2017 May;163(5):646-648. doi: 10.1099/mic.0.000444. Epub 2017 May 22.
Akkermansia muciniphila is an abundant inhabitant of the intestinal tract of humans and many other animals. It is the sole intestinal representative of the verrucomicrobia in human stools and depleted in adults suffering from obesity, diabetes and several other diseases. A. muciniphila degrades intestinal mucin into mainly propionic and acetic acid, and lives in symbiosis with its host, marked by signalling to immune and metabolic pathways, priming trophic chains and likely providing competitive exclusion at the host-microbe interface. Since its recent discovery, A. muciniphila has increasingly been studied and recognized as a true intestinal symbiont promoting beneficial interactions in the intestinal tract.
嗜黏蛋白阿克曼氏菌是人类和许多其他动物肠道中的常见居民。它是人类粪便中疣微菌门的唯一肠道代表菌，在肥胖、糖尿病和其他几种疾病的成年人中数量减少。嗜黏蛋白阿克曼氏菌将肠道黏蛋白主要降解为丙酸和乙酸，并与其宿主共生，其特征是向免疫和代谢途径发出信号、启动营养链，并可能在宿主-微生物界面提供竞争排斥作用。自最近被发现以来，嗜黏蛋白阿克曼氏菌受到了越来越多的研究，并被认为是一种真正的肠道共生菌，可促进肠道内的有益相互作用。
